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Literature DB >> 28931521

PGC1α in the kidney.

Matthew R Lynch¹, Mei T Tran¹, Samir M Parikh¹.

Abstract

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1α make it a prime target for therapeutics aimed at ameliorating AKI, forms of chronic kidney disease (CKD), and their intersection. This review summarizes the current literature on the relationship between renal health and PGC1α and proposes areas of future interest.

Entities: Disease Gene

Keywords: AKI; CKD; PGC1α; kidney; metabolism

Mesh：

Substances：

Year: 2017 PMID： 28931521 PMCID： PMC5866352 DOI： 10.1152/ajprenal.00263.2017

Source DB: PubMed Journal: Am J Physiol Renal Physiol ISSN： 1522-1466

100 in total

1. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Authors: Patrick Weydt; Victor V Pineda; Anne E Torrence; Randell T Libby; Terrence F Satterfield; Eduardo R Lazarowski; Merle L Gilbert; Gregory J Morton; Theodor K Bammler; Andrew D Strand; Libin Cui; Richard P Beyer; Courtney N Easley; Annette C Smith; Dimitri Krainc; Serge Luquet; Ian R Sweet; Michael W Schwartz; Albert R La Spada
Journal: Cell Metab Date: 2006-10-19 Impact factor: 27.287

2. Mitochondrial biogenesis in kidney disease.

Authors: Joel M Weinberg
Journal: J Am Soc Nephrol Date: 2011-02-25 Impact factor: 10.121

3. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes.

Authors: R B Vega; J M Huss; D P Kelly
Journal: Mol Cell Biol Date: 2000-03 Impact factor: 4.272

Review 4. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure.

Authors: Carles Cantó; Johan Auwerx
Journal: Curr Opin Lipidol Date: 2009-04 Impact factor: 4.776

5. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.

Authors: Weiping Qin; Vahram Haroutunian; Pavel Katsel; Christopher P Cardozo; Lap Ho; Joseph D Buxbaum; Giulio M Pasinetti
Journal: Arch Neurol Date: 2009-03

6. A mitochondrial protein compendium elucidates complex I disease biology.

Authors: David J Pagliarini; Sarah E Calvo; Betty Chang; Sunil A Sheth; Scott B Vafai; Shao-En Ong; Geoffrey A Walford; Canny Sugiana; Avihu Boneh; William K Chen; David E Hill; Marc Vidal; James G Evans; David R Thorburn; Steven A Carr; Vamsi K Mootha
Journal: Cell Date: 2008-07-11 Impact factor: 41.582

7. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion.

Authors: Adam Khader; Weng-Lang Yang; Michael Kuncewitch; Asha Jacob; Jose M Prince; Jaya R Asirvatham; Jeffrey Nicastro; Gene F Coppa; Ping Wang
Journal: Transplantation Date: 2014-07-27 Impact factor: 4.939

8. Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage.

Authors: Ya-Ching Hsieh; Mashkoor A Choudhry; Huang-Ping Yu; Tomoharu Shimizu; Shaolong Yang; Takao Suzuki; Jianguo Chen; Kirby I Bland; Irshad H Chaudry
Journal: FASEB J Date: 2006-06 Impact factor: 5.191

9. A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.

Authors: Timothy E Sweeney; Hagir B Suliman; John W Hollingsworth; Karen E Welty-Wolf; Claude A Piantadosi
Journal: PLoS One Date: 2011-09-26 Impact factor: 3.240

Review 10. Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology.

Authors: Ming Zhan; Craig Brooks; Fuyou Liu; Lin Sun; Zheng Dong
Journal: Kidney Int Date: 2013-01-16 Impact factor: 10.612

25 in total

1. Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides.

Authors: Fernando Javier Salazar-Torres; Miguel Medina-Perez; Zesergio Melo; Claudia Mendoza-Cerpa; Raquel Echavarria
Journal: Biomed Rep Date: 2020-11-20

2. An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Authors: Phillip A Dumesic; Daniel F Egan; Philipp Gut; Mei T Tran; Alice Parisi; Nirmalya Chatterjee; Mark Jedrychowski; Margherita Paschini; Lawrence Kazak; Sarah E Wilensky; Florence Dou; Dina Bogoslavski; Jeffrey A Cartier; Norbert Perrimon; Shingo Kajimura; Samir M Parikh; Bruce M Spiegelman
Journal: Cell Metab Date: 2019-05-16 Impact factor: 27.287

3. Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression.

Authors: Justin B Collier; Rick G Schnellmann
Journal: Cell Mol Life Sci Date: 2019-12-23 Impact factor: 9.261

4. Gene deletion of the Na⁺-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion.

Authors: Josselin Nespoux; Rohit Patel; Kelly L Hudkins; Winnie Huang; Brent Freeman; Young Chul Kim; Hermann Koepsell; Charles E Alpers; Volker Vallon
Journal: Am J Physiol Renal Physiol Date: 2019-04-17

5. Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis.

Authors: Tessa Schillemans; Vinicius Tragante; Buamina Maitusong; Bruna Gigante; Sharon Cresci; Federica Laguzzi; Max Vikström; Mark Richards; Anna Pilbrow; Vicky Cameron; Luisa Foco; Robert N Doughty; Pekka Kuukasjärvi; Hooman Allayee; Jaana A Hartiala; W H Wilson Tang; Leo-Pekka Lyytikäinen; Kjell Nikus; Jari O Laurikka; Sundararajan Srinivasan; Ify R Mordi; Stella Trompet; Adriaan Kraaijeveld; Jessica van Setten; Crystel M Gijsberts; Anke H Maitland-van der Zee; Christoph H Saely; Yan Gong; Julie A Johnson; Rhonda M Cooper-DeHoff; Carl J Pepine; Gavino Casu; Andreas Leiherer; Heinz Drexel; Benjamin D Horne; Sander W van der Laan; Nicola Marziliano; Stanley L Hazen; Juha Sinisalo; Mika Kähönen; Terho Lehtimäki; Chim C Lang; Ralph Burkhardt; Markus Scholz; J Wouter Jukema; Niclas Eriksson; Axel Åkerblom; Stefan James; Claes Held; Emil Hagström; John A Spertus; Ale Algra; Ulf de Faire; Agneta Åkesson; Folkert W Asselbergs; Riyaz S Patel; Karin Leander
Journal: Front Physiol Date: 2022-06-23 Impact factor: 4.755

6. Gene knockout of the Na⁺-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion.

Authors: Josselin Nespoux; Rohit Patel; Haiyan Zhang; Winnie Huang; Brent Freeman; Paul W Sanders; Young Chul Kim; Volker Vallon
Journal: Am J Physiol Renal Physiol Date: 2020-03-02

Review 7. Glucose transporters in the kidney in health and disease.

Authors: Volker Vallon
Journal: Pflugers Arch Date: 2020-03-06 Impact factor: 3.657

8. TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression.

Authors: Dakota L Jones; Andrew J Haak; Nunzia Caporarello; Kyoung M Choi; Zhenqing Ye; Huihuang Yan; Xaralabos Varelas; Tamas Ordog; Giovanni Ligresti; Daniel J Tschumperlin
Journal: J Cell Sci Date: 2019-10-18 Impact factor: 5.285

9. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

Authors: Marcus M Seldin; Simon Koplev; Prashant Rajbhandari; Laurent Vergnes; Gregory M Rosenberg; Yonghong Meng; Calvin Pan; Thuy M N Phuong; Raffi Gharakhanian; Nam Che; Selina Mäkinen; Diana M Shih; Mete Civelek; Brian W Parks; Eric D Kim; Frode Norheim; Karthickeyan Chella Krishnan; Yehudit Hasin-Brumshtein; Margarete Mehrabian; Markku Laakso; Christian A Drevon; Heikki A Koistinen; Peter Tontonoz; Karen Reue; Rita M Cantor; Johan L M Björkegren; Aldons J Lusis
Journal: Cell Metab Date: 2018-05-01 Impact factor: 27.287

Review 10. Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial Dysfunction.

Authors: Ravinder K Kaundal; Anil K Kalvala; Ashutosh Kumar
Journal: Mol Neurobiol Date: 2021-06-10 Impact factor: 5.590