Marijana Tadic1, Cesare Cuspidi2, Vladan Vukomanovic3, Sanja Ilic4, Philippe Obert5, Vesna Kocijancic3, Vera Celic6. 1. Department of Cardiology, University Hospital "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address: marijana_tadic@hotmail.com. 2. Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy. 3. Department of Cardiology, University Hospital "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia. 4. Department of Endocrinology, University Hospital "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia. 5. LAPEC EA4278, School of Exercise Science, Avignon University, Avignon, France. 6. Department of Cardiology, University Hospital "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Abstract
BACKGROUND: Detailed analysis of layer-specific mechanical changes in patients with type 2 diabetes mellitus (DM) might improve insight into left ventricular (LV) remodelling and diabetic cardiomyopathy. AIM: We sought to investigate layer-specific LV deformation in patients with DM, with and without hypertension. METHODS: This cross-sectional study included 146 subjects (44 controls; 48 patients with DM; 54 patients with DM and hypertension) who underwent complete examination by two-dimensional echocardiography (2DE), including multilayer strain analysis. RESULTS: 2DE LV longitudinal and circumferential strains deteriorated progressively and significantly from controls, through patients with DM, to patients with DM and hypertension. 2DE radial strain was lower in patients with DM and hypertension than in controls. 2DE longitudinal and circumferential mid-myocardial and epicardial layer strains decreased progressively from controls to patients with DM and hypertension, whereas endocardial layer strain was lower in patients with DM and patients with DM and hypertension than in controls. Variables of DM control (fasting glucose and glycated haemoglobin) were associated with 2DE LV longitudinal and circumferential layer-specific strains, independent of age, body mass index, blood pressure, LV diastolic function and hypertrophy in patients with DM. CONCLUSION: DM and hypertension significantly affect LV deformation assessed by 2DE traditional strain and 2DE multilayer strain. Hypertension showed an additional negative effect on LV deformation in patients with DM. Fasting glucose and glycated haemoglobin were associated with LV mechanics evaluated by comprehensive 2DE strain analysis, independent of LV structure and diastolic function.
BACKGROUND: Detailed analysis of layer-specific mechanical changes in patients with type 2 diabetes mellitus (DM) might improve insight into left ventricular (LV) remodelling and diabetic cardiomyopathy. AIM: We sought to investigate layer-specific LV deformation in patients with DM, with and without hypertension. METHODS: This cross-sectional study included 146 subjects (44 controls; 48 patients with DM; 54 patients with DM and hypertension) who underwent complete examination by two-dimensional echocardiography (2DE), including multilayer strain analysis. RESULTS: 2DE LV longitudinal and circumferential strains deteriorated progressively and significantly from controls, through patients with DM, to patients with DM and hypertension. 2DE radial strain was lower in patients with DM and hypertension than in controls. 2DE longitudinal and circumferential mid-myocardial and epicardial layer strains decreased progressively from controls to patients with DM and hypertension, whereas endocardial layer strain was lower in patients with DM and patients with DM and hypertension than in controls. Variables of DM control (fasting glucose and glycated haemoglobin) were associated with 2DE LV longitudinal and circumferential layer-specific strains, independent of age, body mass index, blood pressure, LV diastolic function and hypertrophy in patients with DM. CONCLUSION:DM and hypertension significantly affect LV deformation assessed by 2DE traditional strain and 2DE multilayer strain. Hypertension showed an additional negative effect on LV deformation in patients with DM. Fasting glucose and glycated haemoglobin were associated with LV mechanics evaluated by comprehensive 2DE strain analysis, independent of LV structure and diastolic function.
Authors: Kun Zhang; Alexander Braun; Francisca von Koeckritz; Rosa B Schmuck; Eva M Teegen; Cesare Cuspidi; Frank Heinzel; Burkert Pieske; Marijana Tadic Journal: J Clin Med Date: 2019-08-22 Impact factor: 4.241
Authors: Velia Cassano; Sofia Miceli; Giuseppe Armentaro; Gaia Chiara Mannino; Vanessa Teresa Fiorentino; Maria Perticone; Elena Succurro; Marta Letizia Hribal; Francesco Andreozzi; Francesco Perticone; Giorgio Sesti; Angela Sciacqua Journal: Nutrients Date: 2022-03-18 Impact factor: 5.717