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Literature DB >> 28925385

Fine-tuning type I IFN signaling: A new chapter in the IFN saga.

Abstract

Type I interferon (IFN) signaling is critical for intracellular antimicrobial programmes, affecting both innate and adaptive immune responses. The paper recently published in Cell demonstrates a new regulatory mechanism of the type I IFN signaling pathway by histone-lysine N-methyltransferase SETD2.

Entities: Gene

Mesh：

Substances：

Year: 2017 PMID： 28925385 PMCID： PMC5717401 DOI： 10.1038/cr.2017.118

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

12 in total

1. A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

Authors: L Velazquez; M Fellous; G R Stark; S Pellegrini
Journal: Cell Date: 1992-07-24 Impact factor: 41.582

Review 2. The STATs of cancer--new molecular targets come of age.

Authors: Hua Yu; Richard Jove
Journal: Nat Rev Cancer Date: 2004-02 Impact factor: 60.716

3. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

Authors: C Schindler; K Shuai; V R Prezioso; J E Darnell
Journal: Science Date: 1992-08-07 Impact factor: 47.728

4. Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

Authors: Kun Chen; Juan Liu; Shuxun Liu; Meng Xia; Xiaomin Zhang; Dan Han; Yingming Jiang; Chunmei Wang; Xuetao Cao
Journal: Cell Date: 2017-07-27 Impact factor: 41.582

5. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

Authors: H Harada; T Fujita; M Miyamoto; Y Kimura; M Maruyama; A Furia; T Miyata; T Taniguchi
Journal: Cell Date: 1989-08-25 Impact factor: 41.582

Fine-tuning type I IFN signaling: A new chapter in the IFN saga.

1. A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

Review 2. The STATs of cancer--new molecular targets come of age.

3. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

4. Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

5. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

6. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

7. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice.

Review 8. The interferons and their receptors--distribution and regulation.

9. Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.

Review 10. SETD2: an epigenetic modifier with tumor suppressor functionality.

1. PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma.