Literature DB >> 28923863

Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis.

Lujuan Gao1, Yi Sun2, Chengyan He3, Tongxiang Zeng3, Ming Li4.   

Abstract

In vitro interactions of tacrolimus, a calcineurin inhibitor, and azoles, including itraconazole, voriconazole, and posaconazole, against planktonic cells and biofilms of Exophiala dermatitidis were assessed via a broth microdilution checkerboard technique. A total of 16 clinical isolates were studied. The results revealed favorable synergistic inhibitory activity between tacrolimus and itraconazole, voriconazole, or posaconazole against 68.8%, 87.5%, and 100% of tested strains of planktonic E. dermatitidis, respectively.However, limited synergism was observed against biofilms of E. dermatitidis No antagonism was observed in all combinations.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Exophiala dermatitidis; FK506; azoles; biofilms; calcineurin inhibitor; synergy; tacrolimus

Mesh：

Substances：

Year:  2017        PMID： 28923863      PMCID： PMC5700337          DOI： 10.1128/AAC.00948-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Fatal Exophiala infections in China, with a report of seven cases.

Authors:  D-M Li; R-Y Li; G S de Hoog; M Sudhadham; D-L Wang
Journal:  Mycoses       Date:  2010-03-22       Impact factor: 4.377

2.  In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.

Authors:  William J Steinbach; Nina Singh; Jackie L Miller; Daniel K Benjamin; Wiley A Schell; Joseph Heitman; John R Perfect
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

3.  High rate of Exophiala dermatitidis recovery in the airways of patients with cystic fibrosis is associated with pancreatic insufficiency.

Authors:  Nahid Kondori; Marita Gilljam; Anders Lindblad; Bodil Jönsson; Edward R B Moore; Christine Wennerås
Journal:  J Clin Microbiol       Date:  2011-01-05       Impact factor: 5.948

4.  The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis.

Authors:  F Shirazi; D P Kontoyiannis
Journal:  Eukaryot Cell       Date:  2013-07-12

Review 5.  Dematiaceous fungi.

Authors:  Sanjay G Revankar
Journal:  Mycoses       Date:  2007-03       Impact factor: 4.377

6.  Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.

Authors:  Priya Uppuluri; Jeniel Nett; Joseph Heitman; David Andes
Journal:  Antimicrob Agents Chemother       Date:  2008-01-07       Impact factor: 5.191

7.  Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Authors:  Leah E Cowen; Sheena D Singh; Julia R Köhler; Cathy Collins; Aimee K Zaas; Wiley A Schell; Hamza Aziz; Eleftherios Mylonakis; John R Perfect; Luke Whitesell; Susan Lindquist
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

Review 8.  Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

Authors:  Praveen R Juvvadi; William J Steinbach
Journal:  Pathogens       Date:  2015-12-16

9.  Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents.

Authors:  Lisa Kirchhoff; Maike Olsowski; Katrin Zilmans; Silke Dittmer; Gerhard Haase; Ludwig Sedlacek; Eike Steinmann; Jan Buer; Peter-Michael Rath; Joerg Steinmann
Journal:  Sci Rep       Date:  2017-02-17       Impact factor: 4.379

10.  Evaluation of the Effects of Photodynamic Therapy Alone and Combined with Standard Antifungal Therapy on Planktonic Cells and Biofilms of Fusarium spp. and Exophiala spp.

Authors:  Lujuan Gao; Shaojie Jiang; Yi Sun; Meiqi Deng; Qingzhi Wu; Ming Li; Tongxiang Zeng
Journal:  Front Microbiol       Date:  2016-04-27       Impact factor: 5.640
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  4 in total

1.  The convoluted process of diagnosing pulmonary mycosis caused by Exophiala dermatitidis: a case report.

Authors:  Zhengtu Li; Jianli Tang; Jinping Zhu; Mingzhou Xie; Shaoqing Huang; Shaoqiang Li; Yangqing Zhan; Weiqi Zeng; Teng Xu; Feng Ye
Journal:  BMC Infect Dis       Date:  2022-05-04       Impact factor: 3.667

2.  Exophiala pneumonia requiring pneumonectomy in a post-renal transplant patient.

Authors:  Adrienne M Gonzales; Kim Minh N Le; Patrick Shin; MaryAnn P Tran
Journal:  IDCases       Date:  2022-03-24

3.  Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Mycobacterium Infection Exacerbated by Exophiala dermatitidis Infection.

Authors:  Yuji Watanabe; Hirohito Sano; Shuichi Konno; Yasuhiro Kamioka; Maya Hariu; Kazuki Takano; Mitsuhiro Yamada; Masafumi Seki
Journal:  Infect Drug Resist       Date:  2022-03-20       Impact factor: 4.003

Review 4.  Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox.

Authors:  Aidan Kane; Dee A Carter
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-14
  4 in total

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