Ping Yin1, Ping Shao2, Huikun Liu2, Weiqin Li2, Leishen Wang2, Jing Wang2, Shuang Zhang2, Junhong Leng2, Nan Li2, Huiguang Tian2, Xilin Yang3, Zhijie Yu4, Gang Hu5. 1. Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pennington Biomedical Research Center, Baton Rouge, LA, USA. 2. Tianjin Women's and Children's Health Center, Tianjin, China. 3. Department of Epidemiology and Biostatistics, Tianjin Medical University, Tianjin, China. 4. Population Cancer Research Program, Dalhousie University, Halifax, NS, Canada. 5. Pennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: gang.hu@pbrc.edu.
Abstract
AIMS: To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. METHODS: A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1-5years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. RESULTS: The multivariable-adjusted odds ratios based on different levels of C-peptide (0-33%, 34-66%, 67-90%, and >90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85-4.39), 2.49 (95% CI 1.06-5.87), and 3.88 (95% CI 1.35-11.1) for diabetes (P for trend <0.0001), and 1.00, 1.66 (95% CI 1.18-2.36), 2.38 (95% CI 1.56-3.62) and 2.35 (95% CI 1.27-4.37) for pre-diabetes (P for trend <0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. CONCLUSIONS: We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.
AIMS: To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. METHODS: A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1-5years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. RESULTS: The multivariable-adjusted odds ratios based on different levels of C-peptide (0-33%, 34-66%, 67-90%, and >90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85-4.39), 2.49 (95% CI 1.06-5.87), and 3.88 (95% CI 1.35-11.1) for diabetes (P for trend <0.0001), and 1.00, 1.66 (95% CI 1.18-2.36), 2.38 (95% CI 1.56-3.62) and 2.35 (95% CI 1.27-4.37) for pre-diabetes (P for trend <0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. CONCLUSIONS: We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.
Authors: F Zhang; L Dong; C P Zhang; B Li; J Wen; W Gao; S Sun; F Lv; H Tian; J Tuomilehto; L Qi; C L Zhang; Z Yu; X Yang; G Hu Journal: Diabet Med Date: 2011-06 Impact factor: 4.359
Authors: Yujie Wang; Liwei Chen; Ke Xiao; Ronald Horswell; Jay Besse; Jolene Johnson; Donna H Ryan; Gang Hu Journal: J Womens Health (Larchmt) Date: 2011-10-24 Impact factor: 2.681
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