Vindana Chibabhai1,2, Trusha Nana3,4, Norma Bosman3,4, Teena Thomas4,5, Warren Lowman4,6. 1. Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. vindana.chibabhai@nhls.ac.za. 2. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. vindana.chibabhai@nhls.ac.za. 3. Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. 4. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 5. Infection Control Services, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. 6. Vermaak and Partners Pathologists, Wits Donald Gordon Medical Centre, Johannesburg, South Africa.
Abstract
PURPOSE: There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS: We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing Enterobacteriaceae. RESULTS: Infections caused by New Delhi beta-lactamase (NDM)-producing Enterobacteriaceae are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing Enterobacteriaceae. CONCLUSIONS: Further good-quality research focused on the treatment of NDM-producing Enterobacteriaceae is warranted.
PURPOSE: There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS: We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing Enterobacteriaceae. RESULTS:Infections caused by New Delhi beta-lactamase (NDM)-producing Enterobacteriaceae are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing Enterobacteriaceae. CONCLUSIONS: Further good-quality research focused on the treatment of NDM-producing Enterobacteriaceae is warranted.
Entities:
Keywords:
Carbapenemase; Enterobacteriaceae; Extensively drug resistant; New Delhi beta-lactamase (NDM); Treatment
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