Yu-Yin Liu1,2, Chien-Hung Liao1, Michele Diana3,4, Shang-Yu Wang1, Seong-Ho Kong5,6,7, Chun-Nan Yeh1, Bernard Dallemagne5, Jacques Marescaux5,6, Ta-Sen Yeh8. 1. Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University, #5, Fu-Hsing Street, Kwei-Shan, Taoyuan, Taiwan. 2. Department of General Surgery, Chang Gung Memorial Hospital, Kaohsiung, Chang Gung University, Kaohsiung, Taiwan. 3. IRCAD, Research Institute Against Cancer of the Digestive System, Strasbourg, France. michele.diana@ircad.fr. 4. Institute of Image-Guided Surgery, IHU-Strasbourg, 1, Place de l'Hôpital, 67095, Strasbourg, France. michele.diana@ircad.fr. 5. IRCAD, Research Institute Against Cancer of the Digestive System, Strasbourg, France. 6. Institute of Image-Guided Surgery, IHU-Strasbourg, 1, Place de l'Hôpital, 67095, Strasbourg, France. 7. Department of Surgery, Seoul National University Hospital, Seoul, South Korea. 8. Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University, #5, Fu-Hsing Street, Kwei-Shan, Taoyuan, Taiwan. tsy471027@adm.cgmh.org.tw.
Abstract
BACKGROUND: Near-infrared (NIR) fluorescence cholangiography by systemic administration of indocyanine green (ICG) enhances the visualization of the biliary tree anatomy. However, the simultaneous enhancement of liver parenchyma can disturb the visualization of critical details. We herein proposed a new technique of NIR cholecystocholangiography by intragallbladder ICG injection to increase the safety during laparoscopic cholecystectomy. METHODS: A total of 46 patients scheduled for laparoscopic cholecystectomy for symptomatic lithiasis (n = 21) or cholecystitis (n = 25) were enrolled. A fluorescence cholangiography by direct gallbladder injection of ICG was performed in all cases. Of them, the ICG was injected through a previously placed percutaneous transhepatic gallbladder drainage catheter (n = 18) or by intraoperative, percutaneous needle puncture of the gallbladder (n = 28). Visualization of biliary structures, including the cystic duct (CD), the common bile and hepatic ducts (CBD and CHD), the gallbladder neck, and the Hartmann's pouch (HP), was performed using White Light (served as control modality) and by NIR enhancement. RESULTS: Cholecystocholangiography provided a significantly higher rate of visualization of the CD in case of cholecystitis with mild adhesions, and an improved visualization of the HP, CBD, and CHD in case of severe inflammation, when compared to White Light observation. There were no benefits of NIR in case of non-inflamed lithiasis. CONCLUSIONS: Clinical translation of NIR cholecystocholangiography has been successful with a noise-free visualization of biliary anatomy. It can be considered in difficult cases to increase the safety of laparoscopic cholecystectomy.
BACKGROUND: Near-infrared (NIR) fluorescence cholangiography by systemic administration of indocyanine green (ICG) enhances the visualization of the biliary tree anatomy. However, the simultaneous enhancement of liver parenchyma can disturb the visualization of critical details. We herein proposed a new technique of NIR cholecystocholangiography by intragallbladder ICG injection to increase the safety during laparoscopic cholecystectomy. METHODS: A total of 46 patients scheduled for laparoscopic cholecystectomy for symptomatic lithiasis (n = 21) or cholecystitis (n = 25) were enrolled. A fluorescence cholangiography by direct gallbladder injection of ICG was performed in all cases. Of them, the ICG was injected through a previously placed percutaneous transhepatic gallbladder drainage catheter (n = 18) or by intraoperative, percutaneous needle puncture of the gallbladder (n = 28). Visualization of biliary structures, including the cystic duct (CD), the common bile and hepatic ducts (CBD and CHD), the gallbladder neck, and the Hartmann's pouch (HP), was performed using White Light (served as control modality) and by NIR enhancement. RESULTS: Cholecystocholangiography provided a significantly higher rate of visualization of the CD in case of cholecystitis with mild adhesions, and an improved visualization of the HP, CBD, and CHD in case of severe inflammation, when compared to White Light observation. There were no benefits of NIR in case of non-inflamed lithiasis. CONCLUSIONS: Clinical translation of NIR cholecystocholangiography has been successful with a noise-free visualization of biliary anatomy. It can be considered in difficult cases to increase the safety of laparoscopic cholecystectomy.
Entities:
Keywords:
Direct intragallbladder; Fluorophore injection; Near-infrared cholangiography
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