BACKGROUND: Attenuation correction using segmentation of scatter and photo-peak window data (SSPAC) enables an evaluation of the attenuation map in a patient-specific manner without additional radiation exposure. We compared the accuracy of SSPAC and non-corrected myocardial perfusion scintigraphy methods for diagnosing the number of stenosed coronary artery vessels. METHODS AND RESULTS: We retrospectively reviewed the data from 183 consecutive patients who underwent 99mTc-tetrofosmin stress/rest SPECT examination and a coronary angiography within 3 months. The MPS images were reconstructed with and without SSPAC attenuation correction. We examined the accuracy of the quantitative interpretation using summed differential score in the detection of coronary artery disease (CAD). The attenuation maps were successfully determined in 179 of 183 patients (98%). In terms of the vessel-based diagnostic ability, sensitivity, specificity, positive predictive and negative predictive values of the SSPAC and non-correction methods for diagnosing CAD in individual coronary territories were 77%*, 89%, 74%*, and 90%* vs 51%, 87%, 62%, and 82%, respectively (*P < .05). In 35 patients with multi-vessel CAD, those values were 78%*, 81%, 93%, and 55%* vs 49%, 81%, 89%, and 34%, respectively (*P < .05; AUC: 0.82 vs 0.62, P < .05). CONCLUSION: SSPAC-corrected SPECT myocardial perfusion images exhibit improved accuracy in the detection of the number of stenosed coronary artery vessels, even in patients with multi-vessel CAD.
BACKGROUND: Attenuation correction using segmentation of scatter and photo-peak window data (SSPAC) enables an evaluation of the attenuation map in a patient-specific manner without additional radiation exposure. We compared the accuracy of SSPAC and non-corrected myocardial perfusion scintigraphy methods for diagnosing the number of stenosed coronary artery vessels. METHODS AND RESULTS: We retrospectively reviewed the data from 183 consecutive patients who underwent 99mTc-tetrofosmin stress/rest SPECT examination and a coronary angiography within 3 months. The MPS images were reconstructed with and without SSPAC attenuation correction. We examined the accuracy of the quantitative interpretation using summed differential score in the detection of coronary artery disease (CAD). The attenuation maps were successfully determined in 179 of 183 patients (98%). In terms of the vessel-based diagnostic ability, sensitivity, specificity, positive predictive and negative predictive values of the SSPAC and non-correction methods for diagnosing CAD in individual coronary territories were 77%*, 89%, 74%*, and 90%* vs 51%, 87%, 62%, and 82%, respectively (*P < .05). In 35 patients with multi-vessel CAD, those values were 78%*, 81%, 93%, and 55%* vs 49%, 81%, 89%, and 34%, respectively (*P < .05; AUC: 0.82 vs 0.62, P < .05). CONCLUSION: SSPAC-corrected SPECT myocardial perfusion images exhibit improved accuracy in the detection of the number of stenosed coronary artery vessels, even in patients with multi-vessel CAD.
Authors: Daniel S Berman; Xingping Kang; Piotr J Slomka; James Gerlach; Ling de Yang; Sean W Hayes; John D Friedman; Louise E J Thomson; Guido Germano Journal: J Nucl Cardiol Date: 2007-07 Impact factor: 5.952
Authors: Harshal R Patil; Timothy M Bateman; A Iain McGhie; Eric V Burgett; Staci A Courter; James A Case; Gary V Heller Journal: J Nucl Cardiol Date: 2013-11-21 Impact factor: 5.952
Authors: Narbeh Melikian; Pieter De Bondt; Pim Tonino; Olivier De Winter; Eric Wyffels; Jozef Bartunek; Guy R Heyndrickx; William F Fearon; Nico H J Pijls; William Wijns; Bernard De Bruyne Journal: JACC Cardiovasc Interv Date: 2010-03 Impact factor: 11.195
Authors: Pim A L Tonino; William F Fearon; Bernard De Bruyne; Keith G Oldroyd; Massoud A Leesar; Peter N Ver Lee; Philip A Maccarthy; Marcel Van't Veer; Nico H J Pijls Journal: J Am Coll Cardiol Date: 2010-06-22 Impact factor: 24.094
Authors: Richard A P Takx; Björn A Blomberg; Hamza El Aidi; Jesse Habets; Pim A de Jong; Eike Nagel; Udo Hoffmann; Tim Leiner Journal: Circ Cardiovasc Imaging Date: 2015-01 Impact factor: 7.792
Authors: T Rehn; L S Griffith; S C Achuff; I K Bailey; B H Bulkley; R Burow; B Pitt; L C Becker Journal: Am J Cardiol Date: 1981-08 Impact factor: 2.778
Authors: Hossein Rajabi; Hadi Taleshi Ahangari; Iraj Mohammadi; Alireza Mohammadkarim; Mohammad Ali Tajik-Mansoury Journal: World J Nucl Med Date: 2020-08-22