BACKGROUND: There have been limited data regarding the value of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for the detection of left main coronary artery disease (CAD). METHODS AND RESULTS: We studied 101 patients with angiographic left main CAD (> or = 50% stenosis) and no prior myocardial infarction or coronary revascularization who underwent gated exercise or adenosine stress technetium 99m sestamibi SPECT MPI. By perfusion assessment alone, high-risk disease with moderate to severe defects (> 10% myocardium at stress) was identified in only 56% of patients visually and 59% quantitatively. Absence of significant perfusion defect (> or = 5% myocardium) was seen in 13% of patients visually and 15% quantitatively. However, by combining visual perfusion data and nonperfusion variables, especially transient ischemic dilation, 83% of patients were identified as high risk. CONCLUSIONS: The findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD.
BACKGROUND: There have been limited data regarding the value of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for the detection of left main coronary artery disease (CAD). METHODS AND RESULTS: We studied 101 patients with angiographic left main CAD (> or = 50% stenosis) and no prior myocardial infarction or coronary revascularization who underwent gated exercise or adenosine stress technetium 99m sestamibi SPECT MPI. By perfusion assessment alone, high-risk disease with moderate to severe defects (> 10% myocardium at stress) was identified in only 56% of patients visually and 59% quantitatively. Absence of significant perfusion defect (> or = 5% myocardium) was seen in 13% of patients visually and 15% quantitatively. However, by combining visual perfusion data and nonperfusion variables, especially transient ischemic dilation, 83% of patients were identified as high risk. CONCLUSIONS: The findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD.
Authors: Piotr J Slomka; Hidetaka Nishina; Daniel S Berman; Cigdem Akincioglu; Aiden Abidov; John D Friedman; Sean W Hayes; Guido Germano Journal: J Nucl Cardiol Date: 2005 Jan-Feb Impact factor: 5.952
Authors: Hidetaka Nishina; Piotr J Slomka; Aiden Abidov; Shunichi Yoda; Cigdem Akincioglu; Xingping Kang; Ishac Cohen; Sean W Hayes; John D Friedman; Guido Germano; Daniel S Berman Journal: J Nucl Med Date: 2006-01 Impact factor: 10.057
Authors: R Hachamovitch; D S Berman; H Kiat; I Cohen; H Lewin; A Amanullah; X Kang; J Friedman; G A Diamond Journal: Am J Cardiol Date: 1997-08-15 Impact factor: 2.778
Authors: Aiden Abidov; Rory Hachamovitch; Sean W Hayes; Chee Keong Ng; Ishac Cohen; John D Friedman; Guido Germano; Daniel S Berman Journal: Circulation Date: 2003-06-09 Impact factor: 29.690
Authors: D S Berman; R Hachamovitch; H Kiat; I Cohen; J A Cabico; F P Wang; J D Friedman; G Germano; K Van Train; G A Diamond Journal: J Am Coll Cardiol Date: 1995-09 Impact factor: 24.094
Authors: Aiden Abidov; Rory Hachamovitch; Alan Rozanski; Sean W Hayes; Marcia M Santos; Maria G Sciammarella; Ishac Cohen; James Gerlach; John D Friedman; Guido Germano; Daniel S Berman Journal: J Am Coll Cardiol Date: 2004-09-01 Impact factor: 24.094
Authors: T Rehn; L S Griffith; S C Achuff; I K Bailey; B H Bulkley; R Burow; B Pitt; L C Becker Journal: Am J Cardiol Date: 1981-08 Impact factor: 2.778
Authors: W Lane Duvall; John A Savino; Elliot J Levine; Luke K Hermann; Lori B Croft; Milena J Henzlova Journal: Eur J Nucl Med Mol Imaging Date: 2014-11-04 Impact factor: 9.236
Authors: Andrea L Vavere; Gregory G Simon; Richard T George; Carlos E Rochitte; Andrew E Arai; Julie M Miller; Marcello Di Carli; Armin Arbab-Zadeh; Armin A Zadeh; Marc Dewey; Hiroyuki Niinuma; Roger Laham; Frank J Rybicki; Joanne D Schuijf; Narinder Paul; John Hoe; Sachio Kuribyashi; Hajime Sakuma; Cesar Nomura; Tan Swee Yaw; Klaus F Kofoed; Kunihiro Yoshioka; Melvin E Clouse; Jeffrey Brinker; Christopher Cox; Joao A C Lima Journal: J Cardiovasc Comput Tomogr Date: 2011-11-12
Authors: Marcio Sommer Bittencourt; Sharmila Dorbala; Michael Steigner; Frank Rybicki; Marcelo Di Carli; Ron Blankstein Journal: J Nucl Cardiol Date: 2012-08 Impact factor: 5.952