Literature DB >> 2890207

The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.

R E Tanzi1, E D Bird, S A Latt, R L Neve.   

Abstract

Complementary DNAs (cDNAs) encoding portions of the amyloid beta protein were used to investigate possible amyloid gene duplication in sporadic Alzheimer's disease. A strategy employing two Eco RI restriction fragment length polymorphisms (RFLPs) detected by the amyloid cDNAs was used. RFLPs allow the detection of a 2:1 gene dosage in the DNA of any individual who is heterozygous for a particular RFLP. The amyloid gene regions homologous to the cDNAs used were not duplicated in the DNA from brains of individuals with sporadic Alzheimer's disease. Similar results were also obtained with a strategy employing a test for 3:2 gene dosage.

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Year:  1987        PMID： 2890207     DOI： 10.1126/science.2890207

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

Review 1.  Current status review: cerebral amyloid.

Authors:  L W Duchen
Journal:  Int J Exp Pathol       Date:  1992-08       Impact factor: 1.925

2.  Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

Authors:  Z Rahmani; J L Blouin; N Creau-Goldberg; P C Watkins; J F Mattei; M Poissonnier; M Prieur; Z Chettouh; A Nicole; A Aurias
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

3.  Protocols to establish genotype-phenotype correlations in Down syndrome.

Authors:  C J Epstein; J R Korenberg; G Annerén; S E Antonarakis; S Aymé; E Courchesne; L B Epstein; A Fowler; Y Groner; J L Huret
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

4.  Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease.

Authors:  N Sacchi; J Nalbantoglu; F R Sergovich; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

5.  2018 Victor A. McKusick Leadership Award: Molecular Mechanisms for Genomic and Chromosomal Rearrangements.

Authors:  James R Lupski
Journal:  Am J Hum Genet       Date:  2019-03-07       Impact factor: 11.025

6.  Widespread expression of amyloid beta-protein precursor gene in rat brain.

Authors:  S Mita; E A Schon; J Herbert
Journal:  Am J Pathol       Date:  1989-06       Impact factor: 4.307

7.  Beta-amyloid gene dosage in Alzheimer's disease.

Authors:  G H Murdoch; L Manuelidis; J H Kim; E E Manuelidis
Journal:  Nucleic Acids Res       Date:  1988-01-11       Impact factor: 16.971

Review 8.  Recent research on the causes of Alzheimer's disease.

Authors:  I J Deary; L J Whalley
Journal:  BMJ       Date:  1988-10-01

Review 9.  Alzheimer's disease--neuropathological aspects.

Authors:  C Bergeron
Journal:  Can J Vet Res       Date:  1990-01       Impact factor: 1.310

Review 10.  Genomic variants, genes, and pathways of Alzheimer's disease: An overview.

Authors:  Adam C Naj; Gerard D Schellenberg
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2017-01       Impact factor: 3.568
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