Literature DB >> 28901838

Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers.

Parinya Panuwet1, Chandresh Ladva1, Dana Boyd Barr1, Tippawan Prapamontol2, John D Meeker3, Priya Esilda D'Souza1, Héctor Maldonado4, P Barry Ryan1, Mark G Robson4.   

Abstract

We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific and nonspecific metabolites of organophosphates (OPs), pyrethroids, select herbicides, and fungicides. Serum was analyzed for total and free testosterone. Linear regression analyses revealed significant negative relationships between total testosterone and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) after controlling for covariates (eg, age, BMI, smoking status). Positive significant associations were found between some OP pesticides and total testosterone. Due to the small sample size and the observational nature of the study, future investigation is needed to confirm our results and to elucidate the biological mechanisms.

Entities:  

Keywords:  Endocrine disruptor; exposures; farmers; pesticides; reproductive health; testosterone

Mesh：

Substances：

Year:  2017        PMID： 28901838      PMCID： PMC6422528          DOI： 10.1080/19338244.2017.1378606

Source DB:  PubMed          Journal:  Arch Environ Occup Health        ISSN： 1933-8244            Impact factor:   1.663


  42 in total

1.  Genetic polymorphisms and activity of PON1 in a Mexican population.

Authors:  A E Rojas-García; M J Solís-Heredia; B Piña-Guzmán; L Vega; L López-Carrillo; B Quintanilla-Vega
Journal:  Toxicol Appl Pharmacol       Date:  2004-12-08       Impact factor: 4.219

2.  Reproductive hormone profile among pesticide factory workers.

Authors:  C Padungtod; B L Lasley; D C Christiani; L M Ryan; X Xu
Journal:  J Occup Environ Med       Date:  1998-12       Impact factor: 2.162

Review 3.  Exposure to environmental endocrine disrupting compounds and men's health.

Authors:  John D Meeker
Journal:  Maturitas       Date:  2010-03-29       Impact factor: 4.342

4.  Paraoxonase 1 status in the Thai population.

Authors:  Wimon Phuntuwate; Chuthamanee Suthisisang; Banhan Koanantakul; Michael I Mackness; Bharti Mackness
Journal:  J Hum Genet       Date:  2005-05-28       Impact factor: 3.172

Review 5.  Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity.

Authors:  Gary Ginsberg; Patricia Neafsey; Dale Hattis; Kathryn Z Guyton; Douglas O Johns; Babasaheb Sonawane
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2009       Impact factor: 6.393

6.  Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D (2,4-dichlorophenoxyacetic acid and picloram) in rats.

Authors:  D J Oakes; W S Webster; P D C Brown-Woodman; H E Ritchie
Journal:  Reprod Toxicol       Date:  2002 May-Jun       Impact factor: 3.143

7.  Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification.

Authors:  Roberto Bravo; Lisa M Caltabiano; Gayanga Weerasekera; Ralph D Whitehead; Carolina Fernandez; Larry L Needham; Asa Bradman; Dana B Barr
Journal:  J Expo Anal Environ Epidemiol       Date:  2004-05

8.  Developing in vitro reporter gene assays to assess the hormone receptor activities of chemicals frequently detected in drinking water.

Authors:  Hong Sun; Chaozong Si; Qian Bian; Xiaodong Chen; Liansheng Chen; Xinru Wang
Journal:  J Appl Toxicol       Date:  2012-08       Impact factor: 3.446

9.  Herbicide metolachlor causes changes in reproductive endocrinology of male wistar rats.

Authors:  Francielle Tatiane Mathias; Renata Marino Romano; Hanan Kaled Sleiman; Claudio Alvarenga de Oliveira; Marco Aurelio Romano
Journal:  ISRN Toxicol       Date:  2012-04-18

Review 10.  Children's exposures to pyrethroid insecticides at home: a review of data collected in published exposure measurement studies conducted in the United States.

Authors:  Marsha K Morgan
Journal:  Int J Environ Res Public Health       Date:  2012-08-17       Impact factor: 3.390
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  4 in total

1.  The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction.

Authors:  Wei Wang; Yucheng Ma; Jiawei Chen; Liao Peng; Xiaoshuai Gao; Lede Lin; Fuxun Zhang; Yang Xiong; Feng Qin; Jiuhong Yuan
Journal:  Front Public Health       Date:  2022-06-24

Review 2.  Impact of environmental toxin exposure on male fertility potential.

Authors:  Sarah C Krzastek; Jack Farhi; Marisa Gray; Ryan P Smith
Journal:  Transl Androl Urol       Date:  2020-12

3.  Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand.

Authors:  Neeranuch Suwannarin; Tippawan Prapamontol; Tomohiko Isobe; Yukiko Nishihama; Yuki Hashimoto; Ampica Mangklabruks; Tawiwan Pantasri; Somporn Chantara; Warangkana Naksen; Shoji F Nakayama
Journal:  Int J Environ Res Public Health       Date:  2021-05-24       Impact factor: 3.390

Review 4.  Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.

Authors:  Wiwat Rodprasert; Jorma Toppari; Helena E Virtanen
Journal:  Front Endocrinol (Lausanne)       Date:  2021-10-07       Impact factor: 5.555
  4 in total

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