Alexander Ivanov1, Devindra S Dabiesingh1, Geetha P Bhumireddy1, Ambreen Mohamed1, Ahmed Asfour1, William M Briggs1, Jean Ho1, Saadat A Khan1, Alexandra Grossman1, Igor Klem1, Terrence J Sacchi1, John F Heitner2. 1. From the Division of Cardiology, Department of Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital (A.I., D.S.D., G.P.B., A.M., A.A., J.H., S.A.K., A.G., T.J.S., J.F.H.); Department of Statistical Sciences, NewYork-Presbyterian Cornell University, Ithaca (W.M.B.); and Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (I.K.). 2. From the Division of Cardiology, Department of Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital (A.I., D.S.D., G.P.B., A.M., A.A., J.H., S.A.K., A.G., T.J.S., J.F.H.); Department of Statistical Sciences, NewYork-Presbyterian Cornell University, Ithaca (W.M.B.); and Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (I.K.). jfh9003@nyp.org.
Abstract
BACKGROUND: Presence of prominent left ventricular trabeculation satisfying criteria for left ventricular noncompaction (LVNC) on routine cardiac magnetic resonance examination is frequently encountered; however, the clinical and prognostic significance of these findings remain elusive. This registry aimed to assess LVNC prevalence by 4 current criteria and to prospectively evaluate an association between diagnosis of LVNC by these criteria and adverse events. METHODS AND RESULTS: There were 700 patients referred for cardiac magnetic resonance: 42% were women, median age was 70 years (range, 45-71 years), mean left ventricular ejection fraction was 51% (±17%), and 32% had late gadolinium enhancement on cardiac magnetic resonance. The cohort underwent diagnostic assessment for LVNC by 4 separate imaging criteria-referenced by their authors as Petersen, Stacey, Jacquier, and Captur, with LVNC prevalence of 39%, 23%, 25% and 3%, respectively. Primary clinical outcome was combined end point of time to death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, and heart failure hospitalization. Secondary clinical outcomes were (1) all-cause mortality and (2) time to the first occurrence of any of the following events: cardiac death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, or heart failure hospitalization. During a median follow-up of 7 years, there were no statistically significant differences in assessed outcomes noted between patients with and without LVNC irrespective of the applied criteria. CONCLUSIONS: Current criteria for the diagnosis of LVNC leads to highly variable disease prevalence in patients referred for cardiac magnetic resonance. The diagnosis of LVNC, by any current criteria, was not associated with adverse clinical events on nearly 7 years of follow-up. Limited conclusions can be made for Captur criteria due to low observed prevalence.
BACKGROUND: Presence of prominent left ventricular trabeculation satisfying criteria for left ventricular noncompaction (LVNC) on routine cardiac magnetic resonance examination is frequently encountered; however, the clinical and prognostic significance of these findings remain elusive. This registry aimed to assess LVNC prevalence by 4 current criteria and to prospectively evaluate an association between diagnosis of LVNC by these criteria and adverse events. METHODS AND RESULTS: There were 700 patients referred for cardiac magnetic resonance: 42% were women, median age was 70 years (range, 45-71 years), mean left ventricular ejection fraction was 51% (±17%), and 32% had late gadolinium enhancement on cardiac magnetic resonance. The cohort underwent diagnostic assessment for LVNC by 4 separate imaging criteria-referenced by their authors as Petersen, Stacey, Jacquier, and Captur, with LVNC prevalence of 39%, 23%, 25% and 3%, respectively. Primary clinical outcome was combined end point of time to death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, and heart failure hospitalization. Secondary clinical outcomes were (1) all-cause mortality and (2) time to the first occurrence of any of the following events: cardiac death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, or heart failure hospitalization. During a median follow-up of 7 years, there were no statistically significant differences in assessed outcomes noted between patients with and without LVNC irrespective of the applied criteria. CONCLUSIONS: Current criteria for the diagnosis of LVNC leads to highly variable disease prevalence in patients referred for cardiac magnetic resonance. The diagnosis of LVNC, by any current criteria, was not associated with adverse clinical events on nearly 7 years of follow-up. Limited conclusions can be made for Captur criteria due to low observed prevalence.
Authors: Francesco Negri; Antonio De Luca; Enrico Fabris; Renata Korcova; Carlo Cernetti; Chrysanthos Grigoratos; Giovanni Donato Aquaro; Gaetano Nucifora; Paolo G Camici; Gianfranco Sinagra Journal: Heart Fail Rev Date: 2019-05 Impact factor: 4.214
Authors: Anna Reka Kiss; Zsófia Gregor; Adam Furak; Attila Tóth; Márton Horváth; Liliana Szabo; Csilla Czimbalmos; Zsofia Dohy; Bela Merkely; Hajnalka Vago; Andrea Szucs Journal: Anatol J Cardiol Date: 2021-08 Impact factor: 1.596