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Literature DB >> 28898693

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8⁺ TILs.

Will Bailis¹, Justin A Shyer¹, Michael Chiorazzi¹, Richard A Flavell².

Abstract

The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8+ TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Fatty Acids
Glucose
Oxygen

Year: 2017 PMID： 28898693 PMCID： PMC6939383 DOI： 10.1016/j.ccell.2017.08.013

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

4 in total

Review 1. Fueling immunity: insights into metabolism and lymphocyte function.

Authors: Erika L Pearce; Maya C Poffenberger; Chih-Hao Chang; Russell G Jones
Journal: Science Date: 2013-10-11 Impact factor: 47.728

Review 2. Metabolic Instruction of Immunity.

Authors: Michael D Buck; Ryan T Sowell; Susan M Kaech; Erika L Pearce
Journal: Cell Date: 2017-05-04 Impact factor: 41.582

Review 3. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.

Authors: Ping-Chih Ho; Susan M Kaech
Journal: Curr Opin Immunol Date: 2017-04-27 Impact factor: 7.486

4. Enhancing CD8⁺ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Authors: Ying Zhang; Raj Kurupati; Ling Liu; Xiang Yang Zhou; Gao Zhang; Abeer Hudaihed; Flavia Filisio; Wynetta Giles-Davis; Xiaowei Xu; Giorgos C Karakousis; Lynn M Schuchter; Wei Xu; Ravi Amaravadi; Min Xiao; Norah Sadek; Clemens Krepler; Meenhard Herlyn; Gordon J Freeman; Joshua D Rabinowitz; Hildegund C J Ertl
Journal: Cancer Cell Date: 2017-09-11 Impact factor: 31.743

4 in total

5 in total

Review 1. Altered Metabolism in Glioblastoma: Myeloid-Derived Suppressor Cell (MDSC) Fitness and Tumor-Infiltrating Lymphocyte (TIL) Dysfunction.

Authors: Natalia Di Ianni; Silvia Musio; Serena Pellegatta
Journal: Int J Mol Sci Date: 2021-04-24 Impact factor: 5.923

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8⁺ TILs.

Review 1. Fueling immunity: insights into metabolism and lymphocyte function.

Review 2. Metabolic Instruction of Immunity.

Review 3. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.

4. Enhancing CD8⁺ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Review 1. Altered Metabolism in Glioblastoma: Myeloid-Derived Suppressor Cell (MDSC) Fitness and Tumor-Infiltrating Lymphocyte (TIL) Dysfunction.

Review 2. Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells.

3. Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.

4. Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway.

Review 5. New insights into molecules and pathways of cancer metabolism and therapeutic implications.

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs.

Review 1. Fueling immunity: insights into metabolism and lymphocyte function.

Review 2. Metabolic Instruction of Immunity.

Review 3. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.

4. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Review 1. Altered Metabolism in Glioblastoma: Myeloid-Derived Suppressor Cell (MDSC) Fitness and Tumor-Infiltrating Lymphocyte (TIL) Dysfunction.

Review 2. Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells.

3. Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System.

4. Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway.

Review 5. New insights into molecules and pathways of cancer metabolism and therapeutic implications.

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8⁺ TILs.

4. Enhancing CD8⁺ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.