Literature DB >> 2889747

Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography.

J Pivonka1, F H Segelman, C A Hartman, W E Segl, N Kucharczyk, R D Sofia.   

Abstract

A manual-injection liquid chromatographic method using fluorescence detection permitted determination of a new antiasthmatic drug, azelastine, and its desmethyl metabolite extracted from human plasma. Reliable quantitation was achieved to at least 0.3 ng/ml for each analyte. No interference was seen in co-chromatography of sixteen other substances, which were potential co-medications (or their metabolites) as used in standard asthma or allergy treatment.

Entities:  

Mesh:

Substances:

Year:  1987        PMID: 2889747     DOI: 10.1016/0378-4347(87)80158-5

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

Review 1.  Clinical pharmacology of new histamine H1 receptor antagonists.

Authors:  F E Simons; K J Simons
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

2.  Determination of Azelastine in Human Plasma by Validated Liquid Chromatography Coupled to Tandom Mass Spectrometry (LC-ESI/MS/MS) for the Clinical Studies.

Authors:  Yoo-Sin Park; Shin-Hee Kim; Young-Jae Kim; Seok-Chul Yang; Min-Ho Lee; Leslie M Shaw; Ju-Seop Kang
Journal:  Int J Biomed Sci       Date:  2010-06
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.