Literature DB >> 2889427

Immunoglobulin lambda light chain genes in rheumatoid arthritis.

D Sidebottom1, D M Grennan, P A Sanders, A Read.   

Abstract

Restriction fragment length polymorphisms (RFLPs) obtained by hybridisation of an immunoglobulin lambda constant region probe to Eco RI digests of genomic deoxyribonucleic acid (DNA) obtained from rheumatoid arthritis (RA) and control subjects have been compared. Polymorphic bands of 8, 13, 18, and 23 kb (kilobases) were shown. The 8/8 genotype and 8 kb allele were increased and the 8/18 genotype and 18 kb allele decreased in the RA group. This effect was independent of HLA and Gm. These findings suggest that genes linked to the loci for the immunoglobulin lambda constant region may influence susceptibility to RA.

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Year:  1987        PMID： 2889427      PMCID： PMC1002204          DOI： 10.1136/ard.46.8.587

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  7 in total

1.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

2.  The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number.

Authors:  M L Anderson; M F Szajnert; J C Kaplan; L McColl; B D Young
Journal:  Nucleic Acids Res       Date:  1984-09-11       Impact factor: 16.971

3.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

4.  Variable amplification of immunoglobulin lambda light-chain genes in human populations.

Authors:  R A Taub; G F Hollis; P A Hieter; S Korsmeyer; T A Waldmann; P Leder
Journal:  Nature       Date:  1983 Jul 14-20       Impact factor: 49.962

5.  [Percutaneous nephrostomy using the Desilets-Hoffman principle].

Authors:  V F Nadalini; N Positano; G Bruttini; M Medica
Journal:  Radiol Med       Date:  1982       Impact factor: 3.469

6.  Gm and Km allotypes in rheumatoid arthritis.

Authors:  P A Sanders; G G de Lange; P A Dyer; D M Grennan
Journal:  Ann Rheum Dis       Date:  1985-08       Impact factor: 19.103

7.  Clustered arrangement of immunoglobulin lambda constant region genes in man.

Authors:  P A Hieter; G F Hollis; S J Korsmeyer; T A Waldmann; P Leder
Journal:  Nature       Date:  1981-12-10       Impact factor: 49.962
  7 in total
  4 in total

1.  An unusual allelic form of the immunoglobulin lambda constant region genes in the Japanese.

Authors:  P H Kay; J Moriuchi; P J Ma; E Saueracker
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  Kappa/lambda immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms.

Authors:  R C Williams; N J Marshall; K Kilpatrick; J Montano; P M Brickell; M Goodall; P A Ealey; B Shine; A P Weetman; R K Craig
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

3.  HLA-linked rheumatoid arthritis.

Authors:  S J Hasstedt; D O Clegg; L Ingles; R H Ward
Journal:  Am J Hum Genet       Date:  1994-10       Impact factor: 11.025

4.  Altered immunoglobulin concentrations and light chain ratios in juvenile onset mixed connective tissue disease.

Authors:  A Haraldsson; H A Tiddens; T Fiselier; J A Bakkeren; C M Weemaes
Journal:  Clin Rheumatol       Date:  1995-01       Impact factor: 2.980
  4 in total

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