Literature DB >> 28892983

Transient Thyrotoxicosis in Molar Pregnancy.

Samarth Virmani1, Sujatha B Srinivas2, Rama Bhat3, Raghavendra Rao4, Ranjini Kudva5.   

Abstract

Molar pregnancy is one of the components of a broader spectrum of diseases known as Gestational Trophoblastic Disease (GTD), presenting with amenorrhoea and irregular bleeding which may be rarely associated with passage of vesicles per vagina. However, it can rarely be associated with hyperthyroidism, which may be associated with clinical features of hyperthyroidism. The following is a report of a 20-year-old woman who presented with amenorrhea followed by irregular bleeding per vagina, thyromegaly and abnormal levels of thyroid hormones. Transvaginal ultrasound revealed features consistent with molar pregnancy. A suction evacuation was done following which serum levels of β-hCG reduced and the levels of thyroid hormones also reduced. On follow up, six weeks later, β-hCG and thyroid hormones were within normal limits. The case and relevant literature are presented here.

Entities:  

Keywords:  Abdominal distension; Hydatidiform mole; Hyperthyroidism

Year:  2017        PMID: 28892983      PMCID: PMC5583778          DOI: 10.7860/JCDR/2017/28561.10133

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  15 in total

1.  Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy.

Authors:  J A Tidy; A M Gillespie; N Bright; C R Radstone; R E Coleman; B W Hancock
Journal:  Gynecol Oncol       Date:  2000-09       Impact factor: 5.482

2.  Severe hyperthyroidism associated with hydatidiform mole.

Authors:  J M Kim; K Arakawa; V McCann
Journal:  Anesthesiology       Date:  1976-05       Impact factor: 7.892

3.  The changing clinical presentation of complete molar pregnancy.

Authors:  V Soto-Wright; M Bernstein; D P Goldstein; R S Berkowitz
Journal:  Obstet Gynecol       Date:  1995-11       Impact factor: 7.661

4.  Hyperthyroidism in the setting of gestational trophoblastic disease.

Authors:  Kanakasabai L Narasimhan; Michel W Ghobrial; Edward B Ruby
Journal:  Am J Med Sci       Date:  2002-05       Impact factor: 2.378

Review 5.  Gestational trophoblastic disease.

Authors:  Elizabeth I O Garner; Donald P Goldstein; Colleen M Feltmate; Ross S Berkowitz
Journal:  Clin Obstet Gynecol       Date:  2007-03       Impact factor: 2.190

6.  Severe hyperthyroidism requiring therapeutic plasmapheresis in a patient with hydatidiform mole.

Authors:  Yeşim Erbil; Deniz Tihan; Adil Azezli; Artur Salmaslioğlu; Yasemin Ozlük; Ahmet Büyükören; Selçuk Ozarmağan
Journal:  Gynecol Endocrinol       Date:  2006-07       Impact factor: 2.260

7.  How long should patients be followed after molar pregnancy? Analysis of serum hCG follow-up data.

Authors:  Jozsef Batorfi; Gyorgy Vegh; Janos Szepesi; Ivan Szigetvari; Jozsef Doszpod; Vilmos Fulop
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2004-01-15       Impact factor: 2.435

8.  Gestational trophoblastic disease.

Authors:  A H Gerulath; T G Ehlen; P Bessette; L Jolicoeur; R Savoie
Journal:  J Obstet Gynaecol Can       Date:  2002-05

Review 9.  Perioperative management of the thyrotoxic patient.

Authors:  Roy W Langley; Henry B Burch
Journal:  Endocrinol Metab Clin North Am       Date:  2003-06       Impact factor: 4.741

10.  Chemotherapy and human chorionic gonadotropin concentrations 6 months after uterine evacuation of molar pregnancy: a retrospective cohort study.

Authors:  Roshan Agarwal; Suliana Teoh; Delia Short; Richard Harvey; Philip M Savage; Michael J Seckl
Journal:  Lancet       Date:  2011-11-28       Impact factor: 79.321

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  4 in total

1.  Functioning Endocrine Tumors in Pregnancy: Diagnostic and Therapeutic Challenges.

Authors:  Kripa E Cherian; Nitin Kapoor; Thomas V Paul; Hesarghatta S Asha
Journal:  Indian J Endocrinol Metab       Date:  2021-12-15

2.  Can Pretreatment Serum Beta-hCG be Used for Predicting Thyrotoxicosis in Gestational Trophoblastic Disease?

Authors:  Uraiwan Khomphaiboonkij; Chanisorn Termsarasab
Journal:  Asian Pac J Cancer Prev       Date:  2021-11-01

3.  Advanced gestational trophoblastic disease: A case report of medical management prior to surgical intervention.

Authors:  Ann Lehto; Kyle Hitscherich; Olga Argeros
Journal:  Case Rep Womens Health       Date:  2018-07-31

4.  Delivery of Euthyroid Baby following Hyperthyroidism in Twin Gestation with Coexisting Complete Hydatidiform Mole.

Authors:  Rishi Raj; Edilfavia Mae Uy; Matthew Hager; Kamyar Asadipooya
Journal:  Case Rep Endocrinol       Date:  2019-12-26
  4 in total

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