| Literature DB >> 28888966 |
Pritesh Prasad1, Ailian Zhang2, Angela A Salim1, Robert J Capon3.
Abstract
Chemical investigation of two Irciniidae sponges collected by hand (SCUBA) from Australian near shore waters, afforded six new examples of a rare class of sesterterpene lactam; ircinialactams B (1), G (2), H (5), and I (6), and 8-hydroxyircinialactams C (3) and G (4); together with the new biosynthetically related lactone, ircinialactone A (7). Also isolated were seven biosynthetically related known Irciniidae metabolites; ircinialactams A (8) and C (9), (7E,12E,20Z,18S)-variabilin (10), (7Z,12Z,20Z,18S)-variabilin (11), (7E,12Z,20Z,18S)-variabilin (12), (7Z,12E,20Z,18S)-variabilin (13) and irciniafuran A (14). The structure elucidation of 1-14 was achieved by detailed spectroscopic analysis, and consideration of a plausible biosynthetic relationship linking Irciniidae sesterterpene β-furans, lactams and lactones.Entities:
Keywords: Irciniidae; Lactam; Marine natural product; Sesterterpene; Sponge; Tetronic acid
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Year: 2017 PMID： 28888966 DOI： 10.1016/j.fitote.2017.09.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882