Erin N Haynes1, Heidi Sucharew2, Timothy J Hilbert3, Pierce Kuhnell4, Alonzo Spencer5, Nicholas C Newman6, Roxanne Burns7, Robert Wright8, Patrick J Parsons9, Kim N Dietrich10. 1. University of Cincinnati, College of Medicine, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, USA. Electronic address: erin.haynes@uc.edu. 2. Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. Electronic address: heidi.sucharew@cchmc.org. 3. University of Cincinnati, College of Medicine, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, USA. Electronic address: hilbertj@ucmail.uc.edu. 4. Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. Electronic address: pierce.kuhnell@cchmc.org. 5. Save Our County Inc., East Liverpool, OH, USA. Electronic address: alonzosspecer@gmail.com. 6. University of Cincinnati, College of Medicine, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, USA; Cincinnati Children's Hospital Medical Center, Division of General and Community Pediatrics, 3333 Burnet Ave, Cincinnati, OH, 45229, USA. Electronic address: nicolas.newman@cchmc.org. 7. Kent State University East Liverpool Campus, 400 E 4th St, East Liverpool, OH, 43920, USA. 8. Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, New York, NY, 10029, USA. Electronic address: robert.wright@mssm.edu. 9. Wadsworth Center, New York State Department of Health, Albany, NY, 12201-0509, USA; University of Albany, School of Public Health, Department of Environmental Health Sciences, 1400 Washington Ave, Albany, NY, 12222, USA. Electronic address: patrick.parsons@health.ny.gov. 10. University of Cincinnati, College of Medicine, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, USA. Electronic address: kim.dietrich@uc.edu.
Abstract
BACKGROUND: East Liverpool, Ohio, the site of a hazardous waste incinerator and a manganese (Mn) processor, has had air Mn concentrations exceeding United States Environmental Protection Agency reference levels for over a decade. Save Our County, Inc., a community organization, was formed to address community environmental health concerns related to local industry. Researchers from the University of Cincinnati partnered with Save Our County to determine if air Mn had an impact on the neurocognitive function of children in the community. METHODS: Children 7-9 years of age from East Liverpool and its surrounding communities, were enrolled (N=106) in the Communities Actively Researching Exposure Study from between March 2013-June 2014. Blood and hair were analyzed for Mn and lead, and serum was analyzed for cotinine. We used linear regression to assess associations between biological measures and IQ subscale scores. RESULTS: Geometric mean blood lead (n=67), blood Mn (n=66), hair Mn (n=98), and serum cotinine (n=69) concentrations were 1.13±1.96μg/dL, 10.06±1.30μg/L, and 360.22±2.17ng/g, 0.76±6.12μg/L respectively. After adjusting for potential confounders, hair Mn was negatively associated with Full Scale IQ. CONCLUSIONS: Hair Mn was negatively associated with child IQ scores. Community partners were instrumental in the conception and implementation of this study.
BACKGROUND: East Liverpool, Ohio, the site of a hazardous waste incinerator and a manganese (Mn) processor, has had air Mn concentrations exceeding United States Environmental Protection Agency reference levels for over a decade. Save Our County, Inc., a community organization, was formed to address community environmental health concerns related to local industry. Researchers from the University of Cincinnati partnered with Save Our County to determine if air Mn had an impact on the neurocognitive function of children in the community. METHODS:Children 7-9 years of age from East Liverpool and its surrounding communities, were enrolled (N=106) in the Communities Actively Researching Exposure Study from between March 2013-June 2014. Blood and hair were analyzed for Mn and lead, and serum was analyzed for cotinine. We used linear regression to assess associations between biological measures and IQ subscale scores. RESULTS: Geometric mean blood lead (n=67), blood Mn (n=66), hair Mn (n=98), and serum cotinine (n=69) concentrations were 1.13±1.96μg/dL, 10.06±1.30μg/L, and 360.22±2.17ng/g, 0.76±6.12μg/L respectively. After adjusting for potential confounders, hair Mn was negatively associated with Full Scale IQ. CONCLUSIONS: Hair Mn was negatively associated with child IQ scores. Community partners were instrumental in the conception and implementation of this study.
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