| Literature DB >> 10482276 |
J H Kordower1, S Palfi, E Y Chen, S Y Ma, T Sendera, E J Cochran, E J Cochran, E J Mufson, R Penn, C G Goetz, C D Comella.
Abstract
As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.Entities:
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Year: 1999 PMID： 10482276 DOI： 10.1002/1531-8249(199909)46:3<419::aid-ana21>3.0.co;2-q
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422