Song Vogue Ahn1, Hyeon Chang Kim2, Chung Mo Nam2, Il Suh3. 1. Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea; Institute of Genomic Cohort, Yonsei University, Wonju, South Korea. 2. Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea. 3. Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: isuh@yuhs.ac.
Abstract
OBJECTIVE: Diabetic women have a greater relative risk of coronary heart disease than diabetic men. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women. METHODS: The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up. RESULTS: The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110mg/dL) compared to normal glucose levels (<100mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (p for interaction with sex=0.021). CONCLUSIONS: The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110mg/dL).
OBJECTIVE:Diabeticwomen have a greater relative risk of coronary heart disease than diabeticmen. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women. METHODS: The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up. RESULTS: The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110mg/dL) compared to normal glucose levels (<100mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (p for interaction with sex=0.021). CONCLUSIONS: The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110mg/dL).
Authors: EunSeok Cha; Francisco J Pasquel; Fengxia Yan; David R Jacobs; Sandra B Dunbar; Guillermo Umpierrez; Yuni Choi; James M Shikany; Michael P Bancks; Jared P Reis; Melissa Spezia Faulkner Journal: Diabetes Res Clin Pract Date: 2021-11-11 Impact factor: 5.602