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Literature DB >> 2888034

Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection.

Abstract

Ex vivo [3H]flunitrazepam receptor occupation was determined in the brain of young, mature and old male Fischer 344 rats after a single intravenous injection of a low dose of diazepam. The two benzodiazepine receptor subtypes or conformations (BZ1 and BZ2) were differentiated by the displacement of [3H]flunitrazepam specific binding with the triazolopyridazine, CL 218,872. The acute diazepam injection decreased ex vivo [3H]flunitrazepam binding in only the senescent rats. The [3H]flunitrazepam binding at both the BZ1 and BZ2 receptor or receptor conformation was significantly reduced in the old rats.

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Year: 1987 PMID： 2888034 DOI： 10.1007/bf00970531

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

32 in total

1. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex.

Authors: H BRODY
Journal: J Comp Neurol Date: 1955-04 Impact factor: 3.215

2. Estimation of hormone receptor affinity by competitive displacement of labeled ligand: effect of concentration of receptor and of labeled ligand.

Authors: S Jacobs; P Cuatrecasas
Journal: Biochem Biophys Res Commun Date: 1975-09-16 Impact factor: 3.575

Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection.

1. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex.

2. Estimation of hormone receptor affinity by competitive displacement of labeled ligand: effect of concentration of receptor and of labeled ligand.

3. Limbic system of the aged mouse.

4. Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor.

Review 5. Heterogeneity of benzodiazepine binding sites: a review of recent research.

6. Loss of axosomatic synapses in the dentate gyrus of aged rats.

7. Benzodiazepine receptor binding in young, mature and senescent rat brain and kidney.

8. Benzodiazepine receptors: preferential stimulation of Type 1 receptors by pentobarbital.

9. Relationship between diazepam dose, plasma level, age, and central nervous system depression.

10. Influence of age and previous use of diazepam dosage required for endoscopy.

Review 1. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.