Aline Donati1,2, Aditya K Gupta3,4, Carolina Jacob5, Benedicte Cavelier-Balloy6, Pascal Reygagne7. 1. Department of Dermatology, University of São Paulo, São Paulo, Brazil. 2. Department of Dermatology, Hospital do Servidor Publico Municipal de São Paulo, São Paulo, Brazil. 3. Mediprobe Research Inc., London, Ontario, Canada. 4. Department of Medicine, University of Toronto, Toronto, Ontario, Canada. 5. Department of Dermatology, University of Mogi das Cruzes, São Paulo, Brazil. 6. Department of Dermatology and Pathology, Saint-Louis Hospital, University of Paris, Paris, France. 7. Centre de Santé Sabouraud, Saint-Louis Hospital, University of Paris, Paris, France.
Abstract
BACKGROUND: Frontal fibrosing alopecia (FFA) differs from lichen planopilaris (LPP) in many clinical aspects, but histology fails to distinguish between these entities. Direct immunofluorescence (DIF) is a diagnostic technique used for autoimmune diseases, including those affecting skin and hair. OBJECTIVE: To characterize DIF patterns in patients with FFA. METHOD: Data was collected retrospectively from FFA cases presenting to the Centre de Santé Sabouraud Hair Clinic in Paris from November 2013 to November 2014. RESULTS: Of 149 patients with FFA, 44 cases underwent DIF. Thirteen cases showed positive results with DIF. Patterns characteristic of LPP and lupus erythematosus were observed, with nearly half showing nonspecific staining. CONCLUSION: DIF patterns in patients with FFA were variable. This diagnostic technique should be used with caution in cases of cicatricial alopecia, particularly FFA.
BACKGROUND:Frontal fibrosing alopecia (FFA) differs from lichen planopilaris (LPP) in many clinical aspects, but histology fails to distinguish between these entities. Direct immunofluorescence (DIF) is a diagnostic technique used for autoimmune diseases, including those affecting skin and hair. OBJECTIVE: To characterize DIF patterns in patients with FFA. METHOD: Data was collected retrospectively from FFA cases presenting to the Centre de Santé Sabouraud Hair Clinic in Paris from November 2013 to November 2014. RESULTS: Of 149 patients with FFA, 44 cases underwent DIF. Thirteen cases showed positive results with DIF. Patterns characteristic of LPP and lupus erythematosus were observed, with nearly half showing nonspecific staining. CONCLUSION: DIF patterns in patients with FFA were variable. This diagnostic technique should be used with caution in cases of cicatricial alopecia, particularly FFA.
Entities:
Keywords:
Cicatricial alopecia; Diagnosis; Hair disorder; Hair loss
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