Literature DB >> 24703641

[Frontal fibrosing alopecia].

C Jouanique1, P Reygagne2.   

Abstract

Frontal fibrosing alopecia (FFA) was first described in 1994. It is characterized by scarring alopecia in bands involving the anterior area of the scalp. Alopecia of the eyebrows is frequently associated, as are pubic, facial and body hair alopecia. The clinical and histologic features are evocative of lichen planopilaris (LPP), and AFF is in fact regarded as a special pattern of LPP. Histology reveals a lymphocytic infiltrate located around the isthmus and follicular infundibulum associated with a decrease in the number of follicles, which are supplanted by fibrous tract. AFF most commonly affects post-menopausal women, but instances have been described in men and in young women. This orphan disease has increased in recent years, with more than 37 articles dedicated to this condition since it was first described in 1994. The pathophysiology remains unknown. The condition develops slowly with spontaneous stabilization over several years but it is impossible to predict the degree of expression prior to stabilization. In this article we review the various treatments proposed, for none of which formal proof of efficacy has been provided to date.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Alopecia; Alopécie cicatricielle; Alopécie frontale fibrosante; Cicatricial alopecia; Eyebrow alopecia; Fibrose; Fibrosis; Kossard; Lichen plan pilaire; Lichen planopilaris; Lichen planus; Menopause; Ménopause; Scarring alopecia; Sourcils

Mesh:

Year:  2014        PMID: 24703641     DOI: 10.1016/j.annder.2014.01.020

Source DB:  PubMed          Journal:  Ann Dermatol Venereol        ISSN: 0151-9638            Impact factor:   0.777


  2 in total

1.  The Use of Direct Immunofluorescence in Frontal Fibrosing Alopecia.

Authors:  Aline Donati; Aditya K Gupta; Carolina Jacob; Benedicte Cavelier-Balloy; Pascal Reygagne
Journal:  Skin Appendage Disord       Date:  2017-04-01

Review 2.  DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms.

Authors:  Neide Kalil Gaspar
Journal:  An Bras Dermatol       Date:  2016 Nov-Dec       Impact factor: 1.896

  2 in total

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