INTRODUCTION: Instrumenting timed functional motor tasks may reveal a continuum of motor disability that predicts future motor dysfunction. METHODS: We performed a prospective study of the instrumented timed up and go (iTUG) test in genetically confirmed facioscapulohumeral muscular dystrophy (FSHD) participants using a commercially available system of wireless motion sensors. Patients returned within 2 weeks to determine test-retest reliability. Gait parameters in FSHD participants were compared with a normative database, FSHD clinical severity score, manual muscle testing, and patient-reported functional disability. RESULTS: Gait parameters in FSHD participants were significantly (P < 0.05) altered compared with normative values, and reliability was excellent (intraclass correlation coefficient 0.84-0.99). Stride velocity and trunk sagittal range of motion had moderate to strong correlations to other FSHD disease measures. DISCUSSION: The iTUG was reliable, abnormal in FSHD, and could distinguish between participants with differing disease severities. Instrumenting timed functional tasks may prove to be useful in FSHD clinical trials. Muscle Nerve 57: 503-506, 2018.
INTRODUCTION: Instrumenting timed functional motor tasks may reveal a continuum of motor disability that predicts future motor dysfunction. METHODS: We performed a prospective study of the instrumented timed up and go (iTUG) test in genetically confirmed facioscapulohumeral muscular dystrophy (FSHD) participants using a commercially available system of wireless motion sensors. Patients returned within 2 weeks to determine test-retest reliability. Gait parameters in FSHDparticipants were compared with a normative database, FSHD clinical severity score, manual muscle testing, and patient-reported functional disability. RESULTS: Gait parameters in FSHDparticipants were significantly (P < 0.05) altered compared with normative values, and reliability was excellent (intraclass correlation coefficient 0.84-0.99). Stride velocity and trunk sagittal range of motion had moderate to strong correlations to other FSHD disease measures. DISCUSSION: The iTUG was reliable, abnormal in FSHD, and could distinguish between participants with differing disease severities. Instrumenting timed functional tasks may prove to be useful in FSHD clinical trials. Muscle Nerve 57: 503-506, 2018.
Authors: M Iosa; C Mazzà; R Frusciante; M Zok; I Aprile; E Ricci; A Cappozzo Journal: Clin Biomech (Bristol, Avon) Date: 2007-09-11 Impact factor: 2.063
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Authors: Jeffrey M Statland; Craig Campbell; Urvi Desai; Chafic Karam; Jordi Díaz-Manera; Jeffrey T Guptill; Lawrence Korngut; Angela Genge; Rabi N Tawil; Lauren Elman; Nanette C Joyce; Kathryn R Wagner; Georgios Manousakis; Anthony A Amato; Russell J Butterfield; Perry B Shieh; Matthew Wicklund; Josep Gamez; Cynthia Bodkin; Alan Pestronk; Conrad C Weihl; Juan J Vilchez-Padilla; Nicholas E Johnson; Katherine D Mathews; Barry Miller; Ashley Leneus; Marcie Fowler; Marc van de Rijn; Kenneth M Attie Journal: Muscle Nerve Date: 2022-05-09 Impact factor: 3.852