Adrienn Katalin Poór1, Fanni Rencz2, Valentin Brodszky3, László Gulácsi3, Zsuzsanna Beretzky3,4, Bernadett Hidvégi1, Péter Holló1, Sarolta Kárpáti1, Márta Péntek3. 1. Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária utca 41, 1085, Budapest, Hungary. 2. Department of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary. fanni.rencz@uni-corvinus.hu. 3. Department of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary. 4. Doctoral School of Business and Management, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.
Abstract
The purpose of this study is to assess the measurement properties of EQ-5D-5L compared to EQ-5D-3L in psoriasis patients. METHODS: A cross-sectional survey was carried out at an academic dermatology clinic in Hungary. Psoriasis patients completed the EQ-5D-3L, EQ-5D-5L and Dermatology Life Quality Index (DLQI) questionnaires, and Psoriasis Area and Severity Index (PASI) was assessed. The UK value sets were used to calculate the 3L and 5L index scores. We tested the feasibility, ceiling effect, redistribution properties, the level of inconsistency and informativity (Shannon and Shannon Evenness indices). Spearman's rank-order correlations were performed between EQ-5D, EQ VAS, DLQI and PASI scores. Known-groups validity was evaluated by comparing age groups, clinical subtypes and treatment groups. RESULTS: Mean age of the 238 patients was 47 years, and 36.6% of them received biological therapy. Mean EQ-5D index score was 0.77 (SD: 0.26) with the 3L and 0.84 (SD: 0.19) with the 5L. The overall ceiling effect decreased from 37.1 (3L) to 32.9% (5L). Shannon index improved significantly for most dimensions, but Shannon Evenness index improved only in three dimensions. Compared to the 3L, the 5L version confirmed a better convergent validity with PASI, but not with the DLQI. Known-groups validity was equally demonstrated both for the 5L and 3L. CONCLUSIONS: The EQ-5D-5L seems to improve measurement properties by reducing ceiling effects, strengthening correlations with PASI and improving informativity. Follow-up studies are needed to test responsiveness and reliability in psoriasis.
The purpose of this study is to assess the measurement properties of EQ-5D-5L compared to EQ-5D-3L in psoriasispatients. METHODS: A cross-sectional survey was carried out at an academic dermatology clinic in Hungary. Psoriasispatients completed the EQ-5D-3L, EQ-5D-5L and Dermatology Life Quality Index (DLQI) questionnaires, and Psoriasis Area and Severity Index (PASI) was assessed. The UK value sets were used to calculate the 3L and 5L index scores. We tested the feasibility, ceiling effect, redistribution properties, the level of inconsistency and informativity (Shannon and Shannon Evenness indices). Spearman's rank-order correlations were performed between EQ-5D, EQ VAS, DLQI and PASI scores. Known-groups validity was evaluated by comparing age groups, clinical subtypes and treatment groups. RESULTS: Mean age of the 238 patients was 47 years, and 36.6% of them received biological therapy. Mean EQ-5D index score was 0.77 (SD: 0.26) with the 3L and 0.84 (SD: 0.19) with the 5L. The overall ceiling effect decreased from 37.1 (3L) to 32.9% (5L). Shannon index improved significantly for most dimensions, but Shannon Evenness index improved only in three dimensions. Compared to the 3L, the 5L version confirmed a better convergent validity with PASI, but not with the DLQI. Known-groups validity was equally demonstrated both for the 5L and 3L. CONCLUSIONS: The EQ-5D-5L seems to improve measurement properties by reducing ceiling effects, strengthening correlations with PASI and improving informativity. Follow-up studies are needed to test responsiveness and reliability in psoriasis.
Authors: Daniel S J Costa; Rebecca Mercieca-Bebber; Claudia Rutherford; Margaret-Ann Tait; Madeleine T King Journal: Qual Life Res Date: 2021-04-01 Impact factor: 4.147
Authors: Fanni Rencz; Peter L Lakatos; László Gulácsi; Valentin Brodszky; Zsuzsanna Kürti; Szilvia Lovas; János Banai; László Herszényi; Tamás Cserni; Tamás Molnár; Márta Péntek; Károly Palatka Journal: Qual Life Res Date: 2018-09-17 Impact factor: 4.147
Authors: Anne Simone Juhl Christiansen; Marie Louise Sletskov Møller; Christian Kronborg; Ketil Jørgen Haugan; Lars Køber; Søren Højberg; Axel Brandes; Claus Graff; Søren Zöga Diederichsen; Jonas Bille Nielsen; Derk Krieger; Anders Gaarsdal Holst; Jesper Hastrup Svendsen Journal: Eur J Health Econ Date: 2021-03-18