| Literature DB >> 28873473 |
Kun Yun Lee1, Wan Azman Wan Ahmad2, Ee Vien Low3, Siow Yen Liau4,5, Lawrence Anchah6, Syuhada Hamzah7, Houng-Bang Liew5,8, Rosli B Mohd Ali9, Omar Ismail10, Tiong Kiam Ong11, Mas Ayu Said1, Maznah Dahlui1.
Abstract
INTRODUCTION: The increasing disease burden of coronary artery disease (CAD) calls for sustainable cardiac service. Teaching hospitals and general hospitals in Malaysia are main providers of percutaneous coronary intervention (PCI), a common treatment for CAD. Few studies have analyzed the contemporary data on local cardiac facilities. Service expansion and budget allocation require cost evidence from various providers. We aim to compare the patient characteristics, procedural outcomes, and cost profile between a teaching hospital (TH) and a general hospital (GH).Entities:
Mesh:
Year: 2017 PMID: 28873473 PMCID: PMC5584952 DOI: 10.1371/journal.pone.0184410
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 1Pathway for the costing analysis of elective PCI.
Comparison of patient characteristics at TH and GH.
| TH | n = 375 | GH | n = 240 | p value | |
|---|---|---|---|---|---|
| n | % | n | % | ||
| Age, mean ± SD, years | 60.1 | 10.1 | 58.2 | 10.6 | 0.029 |
| Age>60 | 183 | 48.8 | 135 | 56.2 | 0.187 |
| Male Gender | 272 | 72.5 | 208 | 86.7 | <0.001 |
| History of Smoking | 211 | 56.3 | 140 | 58.3 | 0.613 |
| Dyslipidaemia | 251 | 71.1 | 163 | 72.1 | 0.791 |
| Hypertension | 269 | 74.7 | 164 | 71.6 | 0.405 |
| Diabetes Mellitus | 183 | 54.0 | 73 | 32.0 | <0.001 |
| Body Mass Index ≥ 25 | 243 | 64.8 | 143 | 59.6 | 0.192 |
| Family history of CVD | 130 | 36.1 | 65 | 28.9 | 0.071 |
| Cerebrovascular Disease | 10 | 2.7 | 2 | 0.9 | 0.124 |
| Peripheral Vascular Disease | 1 | 0.3 | 1 | 0.4 | 0.726 |
| Chronic Renal Failure | 21 | 5.7 | 7 | 3.1 | 0.142 |
| Documented CAD | 185 | 52.1 | 78 | 35.0 | <0.001 |
| New onset angina | 89 | 25.1 | 42 | 17.7 | 0.033 |
| Previous Heart Failure | 8 | 2.2 | 19 | 8.4 | <0.001 |
| Previous MI | 119 | 33.2 | 91 | 42.9 | 0.021 |
| Previous PCI | 156 | 41.6 | 48 | 20.4 | <0.001 |
| Previous CABG | 8 | 2.1 | 3 | 1.2 | 0.420 |
| NYHA II-IV | 92 | 25.0 | 35 | 14.7 | 0.002 |
| CCS 2–4 | 215 | 57.8 | 78 | 32.6 | <0.001 |
| Acute Coronary Syndrome | 78 | 20.8 | 33 | 13.8 | 0.027 |
Risk factors, NYHA, CCS have missing data (<5%).
The percentages were determined from the available data.
Comparison of procedural details and outcomes at TH and GH.
| TH | n = 375 | GH | n = 240 | p value | |
|---|---|---|---|---|---|
| n | % | n | % | ||
| Thrombolytics | 7 | 1.9 | 8 | 3.3 | 0.250 |
| Glycoprotein 2b/3a | 27 | 7.2 | 5 | 2.1 | 0.005 |
| Femoral | 137 | 36.5 | 73 | 30.4 | 0.119 |
| Radial | 255 | 68 | 169 | 70.4 | 0.528 |
| Left Anterior Descending | 196 | 52.3 | 170 | 70.8 | <0.001 |
| Left Circumflex | 107 | 28.5 | 62 | 25.8 | 0.464 |
| Right Coronary | 139 | 37.1 | 89 | 37.1 | 0.997 |
| Left Main Stem | 7 | 1.9 | 3 | 1.2 | 0.555 |
| 56 | 14.9 | 66 | 27.5 | <0.001 | |
| 1.71± 0.81 | 1.53±0.76 | 0.007 | |||
| Ostial | 8 | 2.1 | 10 | 4.2 | 0.144 |
| Total Occlusion | 13 | 3.5 | 12 | 5 | 0.348 |
| Chronic Total Occlusion | 26 | 6.9 | 8 | 3.3 | 0.057 |
| Thrombus in lesion | 9 | 2.4 | 4 | 2.2 | 0.797 |
| Bifurcation | 8 | 2.1 | 14 | 5.8 | 0.016 |
| LMS | 7 | 1.9 | 1 | 0.4 | 0.122 |
| Calcified lesion | 46 | 12.3 | 9 | 3.8 | <0.001 |
| 216 | 57.6 | 132 | 55.0 | 0.263 | |
| Stents placed per patient, mean ± SD | 1.27±0.79 | 1.16±0.66 | 0.072 | ||
| DES placed per patient, mean ± SD | 1.00±0.79 | 1.00±0.65 | 0.964 | ||
| BMS placed per patient, mean ± SD | 0.06±0.30 | 0.10±0.40 | 0.131 | ||
| BVS placed per patient, mean ± SD | 0.02±0.17 | 0.03±0.22 | 0.356 | ||
| DEB placed per patient, mean ± SD | 0.19±0.51 | 0.03±0.18 | <0.001 | ||
| TIMI-3 post PCI | 361 | 96.3 | 229 | 95.4 | 0.603 |
| Successful Revascularization | 354 | 94.4 | 231 | 96.2 | 0.299 |
| In-hospital Mortality | 0 | 0 | 2 | 0.8 | 0.077 |
| Non-MACCE Complications | 3 | 0.8 | 0 | 0 | 0.165 |
Note. DES = drug eluting stent, BMS = bare metal stent, BVS = bioresorbable vascular scaffold, DEB = drug-eluting balloon.
a Each patient may have more than one percutaneous entry, diseased vessels and stents inserted.
Comparison of length of stay and costs of PCI at TH and GH.
| TH (n = 375) | GH (n = 240) | p value | ||
|---|---|---|---|---|
| Mean±SD | 4.8±8.6 | 3.7±6.3 | 0.08 | |
| Median (IQR) | 2.0 (2.0–3.0) | 2.0 (1.0–3.0) | ||
| Mean±SD | 4344.81±7809.66 | 3075.56±5123.15 | <0.001 | |
| Median (IQR) | 1813.36 (1813.36–2720.04) | 1637.06 (818.53–2455.59) | ||
| Mean±SD | 8084.45±4329.29 | 7645.15±3551.71 | <0.001 | |
| Median (IQR) | 7299.91(5999.91–11099.91) | 7535.57 (5135.57–7810.57) | ||
| Mean±SD | 11906.44±4329.29 | 8993.27±3551.71 | <0.001 | |
| Median (IQR) | 11121.90 (9821.90–14921.90) | 8883.69 (6483.69–9158.69) | ||
| Mean± SD | 16289.17±8820.91 | 12117.45±6139.60 | <0.001 | |
| Median (IQR) | 13173.18 (11973.18–18173.18) | 10569.37 (8854.59–14333.70) | ||
Note. All costs are in Ringgit Malaysia (RM). LOS and cost are not normally distributed. Levene's test of normality showed p<0.05. Mann Whitney test used to compare the mean differences.
a Included cost of cardiac catheterization laboratory utilization and PCI consumables.