Literature DB >> 28864901

Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression.

I R Abjalimov1, M V Zinovyeva1, L G Nikolaev2, M R Kopantzeva1, E P Kopantzev1, E D Sverdlov1.   

Abstract

The expression level of six transcription factor genes and the content of their protein products in five pancreatic cancer cell lines with parallel control of expression of three marker genes reflecting epithelial or mesenchymal state of cells was investigated. Cell lines MIA PaCa-2 and Capan-2 represented the best models of quasi-mesenchymal and epithelial, respectively, types of progression of the pancreatic ductal adenocarcinoma, according to the content of E-cadherin and vimentin and the expression of KLF5 and ZEB1 transcription factors.

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Year:  2017        PMID： 28864901     DOI： 10.1134/S160767291704007X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  11 in total

Review 1.  [SNAI1 and SNAI2 - transcriptional master-regulators of epithelial-mesenchimal transition].

Authors:  E V Usova; M R Kopantseva; V I Egorov; E P Kopantzev; E D Sverdlov
Journal:  Patol Fiziol Eksp Ter       Date:  2015 Apr-Jun

2.  Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening.

Authors:  Agnieszka B Bialkowska; Melissa Crisp; Thomas Bannister; Yuanjun He; Sarwat Chowdhury; Stephan Schürer; Peter Chase; Timothy Spicer; Franck Madoux; Chenlu Tian; Peter Hodder; Daniel Zaharevitz; Vincent W Yang
Journal:  Mol Cancer Ther       Date:  2011-09-01       Impact factor: 6.261

3.  TGF-β Tumor Suppression through a Lethal EMT.

Authors:  Charles J David; Yun-Han Huang; Mo Chen; Jie Su; Yilong Zou; Nabeel Bardeesy; Christine A Iacobuzio-Donahue; Joan Massagué
Journal:  Cell       Date:  2016-02-18       Impact factor: 41.582

Review 4.  The epithelial to mesenchymal transition in pancreatic cancer: A systematic review.

Authors:  Mircea Beuran; Ionut Negoi; Sorin Paun; Adriana Daniela Ion; Coralia Bleotu; Ruxandra Irina Negoi; Sorin Hostiuc
Journal:  Pancreatology       Date:  2015-03-07       Impact factor: 3.996

Review 5.  The basics of epithelial-mesenchymal transition.

Authors:  Raghu Kalluri; Robert A Weinberg
Journal:  J Clin Invest       Date:  2009-06       Impact factor: 14.808

6.  Dissection of transcriptional and cis-regulatory control of differentiation in human pancreatic cancer.

Authors:  Giuseppe R Diaferia; Chiara Balestrieri; Elena Prosperini; Paola Nicoli; Paola Spaggiari; Alessandro Zerbi; Gioacchino Natoli
Journal:  EMBO J       Date:  2016-01-14       Impact factor: 11.598

7.  Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer.

Authors:  J A Galván; I Zlobec; M Wartenberg; A Lugli; B Gloor; A Perren; E Karamitopoulou
Journal:  Br J Cancer       Date:  2015-05-19       Impact factor: 7.640

8.  Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants.

Authors:  Robert Petryszak; Maria Keays; Y Amy Tang; Nuno A Fonseca; Elisabet Barrera; Tony Burdett; Anja Füllgrabe; Alfonso Muñoz-Pomer Fuentes; Simon Jupp; Satu Koskinen; Oliver Mannion; Laura Huerta; Karine Megy; Catherine Snow; Eleanor Williams; Mitra Barzine; Emma Hastings; Hendrik Weisser; James Wright; Pankaj Jaiswal; Wolfgang Huber; Jyoti Choudhary; Helen E Parkinson; Alvis Brazma
Journal:  Nucleic Acids Res       Date:  2015-10-19       Impact factor: 16.971

9.  Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.

Authors:  Yulia V Skvortsova; Sofia A Kondratieva; Marina V Zinovyeva; Lev G Nikolaev; Tatyana L Azhikina; Ildar V Gainetdinov
Journal:  PLoS One       Date:  2016-06-01       Impact factor: 3.240

10.  Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

Authors:  Xiaofeng Zheng; Julienne L Carstens; Jiha Kim; Matthew Scheible; Judith Kaye; Hikaru Sugimoto; Chia-Chin Wu; Valerie S LeBleu; Raghu Kalluri
Journal:  Nature       Date:  2015-11-11       Impact factor: 49.962
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  3 in total

Review 1.  Inherited pancreatic cancer.

Authors:  Fei Chen; Nicholas J Roberts; Alison P Klein
Journal:  Chin Clin Oncol       Date:  2017-12

2.  Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer.

Authors:  M V Zinovyeva; L G Nikolaev; L G Kondratyeva; T V Vinogradova; E D Sverdlov
Journal:  Dokl Biochem Biophys       Date:  2018-08-31       Impact factor: 0.788

3.  PDX1, a key factor in pancreatic embryogenesis, can exhibit antimetastatic activity in pancreatic ductal adenocarcinoma.

Authors:  Liya G Kondratyeva; Dina R Safina; Igor P Chernov; Eugene P Kopantzev; Sergey V Kostrov; Eugene D Sverdlov
Journal:  Cancer Manag Res       Date:  2019-07-26       Impact factor: 3.989
  3 in total

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