Literature DB >> 28864895

The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity.

M A Vasilenko1, E V Kirienkova1, D A Skuratovskaia1, P A Zatolokin1,2, N I Mironyuk2, L S Litvinova3.   

Abstract

We investigated the tissue-specific features of the production of adipokines (leptin and adipsin) by adipose tissue in obese patients depending on the degree of obesity and the state of carbohydrate metabolism. An increase in the content of adipsin and leptin in the blood plasma was found. In patients with varying degrees of obesity with and without type 2 diabetes mellitus (DM 2), we determined the level of tissue-specific expression of LEP and CFD genes encoding leptin and adipsin, respectively. The contribution of different adipose tissue depots to the blood plasma level of adipsin and leptin in obese patients with and without DM 2 was established. The disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance.

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Year:  2017        PMID： 28864895     DOI： 10.1134/S160767291704010X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  9 in total

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2.  Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

Authors:  C T Montague; J B Prins; L Sanders; J E Digby; S O'Rahilly
Journal:  Diabetes       Date:  1997-03       Impact factor: 9.461

Review 3.  Counterregulation of insulin by leptin as key component of autonomic regulation of body weight.

Authors:  Katarina T Borer
Journal:  World J Diabetes       Date:  2014-10-15

4.  Adipsin is an adipokine that improves β cell function in diabetes.

Authors:  James C Lo; Sanda Ljubicic; Barbara Leibiger; Matthias Kern; Ingo B Leibiger; Tilo Moede; Molly E Kelly; Diti Chatterjee Bhowmick; Incoronata Murano; Paul Cohen; Alexander S Banks; Melin J Khandekar; Arne Dietrich; Jeffrey S Flier; Saverio Cinti; Matthias Blüher; Nika N Danial; Per-Olof Berggren; Bruce M Spiegelman
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7.  Subcutaneous and omental fat expression of adiponectin and leptin in women with polycystic ovary syndrome.

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  9 in total
  15 in total

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2.  Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects.

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3.  Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial.

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Journal:  Diabetol Metab Syndr       Date:  2019-08-05       Impact factor: 3.320

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9.  Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease.

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Journal:  J Am Heart Assoc       Date:  2019-11-22       Impact factor: 5.501

10.  Association of Metabolically Healthy and Unhealthy Obesity Phenotype with Markers Related to Obesity, Diabetes among Young, Healthy Adult Men. Analysis of MAGNETIC Study.

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