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Literature DB >> 28864714

A new modification for mammalian messenger RNA.

Abstract

The discovery of multiple RNA modifications in the past few years has broadened our views of the structures and potential functions of RNA species, but deciphering which modifications are made where and how remains a challenge. A new study by Xu et al. applies a combination of mass spectrometry, biochemistry, genetics, and cellular biology tools to reveal the two mammalian methyltransferases that are responsible for m3C installation in tRNA and a third that mediates the previously unknown installation of m3C in mammalian mRNA.

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Year: 2017 PMID： 28864714 PMCID： PMC5582860 DOI： 10.1074/jbc.H117.798298

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

10 in total

1. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.

Authors: Sonia D'Silva; Steffen J Haider; Eric M Phizicky
Journal: RNA Date: 2011-04-25 Impact factor: 4.942

2. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.

Authors: Akiko Noma; Sanghyun Yi; Takayuki Katoh; Yoshimi Takai; Takeo Suzuki; Tsutomu Suzuki
Journal: RNA Date: 2011-04-25 Impact factor: 4.942

Review 3. Dynamic RNA Modifications in Gene Expression Regulation.

Authors: Ian A Roundtree; Molly E Evans; Tao Pan; Chuan He
Journal: Cell Date: 2017-06-15 Impact factor: 41.582

4. Methylated bases of ribosomal ribonucleic acid from HeLa cells.

Authors: Y Iwanami; G M Brown
Journal: Arch Biochem Biophys Date: 1968-07 Impact factor: 4.013

5. Only one of two closely related yeast suppressor tRNA genes contains an intervening sequence.

Authors: M V Olson; G S Page; A Sentenac; P W Piper; M Worthington; R B Weiss; B D Hall
Journal: Nature Date: 1981-06-11 Impact factor: 49.962

6. Three distinct 3-methylcytidine (m³C) methyltransferases modify tRNA and mRNA in mice and humans.

Authors: Luang Xu; Xinyu Liu; Na Sheng; Kyaw Soe Oo; Junxin Liang; Yok Hian Chionh; Juan Xu; Fuzhou Ye; Yong-Gui Gao; Peter C Dedon; Xin-Yuan Fu
Journal: J Biol Chem Date: 2017-06-27 Impact factor: 5.157

7. Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis.

Authors: Lee E Vandivier; Rafael Campos; Pavel P Kuksa; Ian M Silverman; Li-San Wang; Brian D Gregory
Journal: Plant Cell Date: 2015-11-11 Impact factor: 11.277

8. tRNA base methylation identification and quantification via high-throughput sequencing.

Authors: Wesley C Clark; Molly E Evans; Dan Dominissini; Guanqun Zheng; Tao Pan
Journal: RNA Date: 2016-09-09 Impact factor: 4.942

9. S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.

Authors: Lu Han; Erin Marcus; Sonia D'Silva; Eric M Phizicky
Journal: RNA Date: 2016-12-21 Impact factor: 4.942

10. ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments.

Authors: Aaron E Cozen; Erin Quartley; Andrew D Holmes; Eva Hrabeta-Robinson; Eric M Phizicky; Todd M Lowe
Journal: Nat Methods Date: 2015-08-03 Impact factor: 28.547

10 in total

5 in total

A new modification for mammalian messenger RNA.

1. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.

2. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.

Review 3. Dynamic RNA Modifications in Gene Expression Regulation.

4. Methylated bases of ribosomal ribonucleic acid from HeLa cells.

5. Only one of two closely related yeast suppressor tRNA genes contains an intervening sequence.

6. Three distinct 3-methylcytidine (m³C) methyltransferases modify tRNA and mRNA in mice and humans.

7. Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis.

8. tRNA base methylation identification and quantification via high-throughput sequencing.

9. S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.

10. ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments.

Review 1. Epitranscriptomic Code and Its Alterations in Human Disease.

2. Emerging roles of RNA modifications in genome integrity.

Review 3. A Census and Categorization Method of Epitranscriptomic Marks.

4. Nucleotide resolution profiling of m3C RNA modification by HAC-seq.

5. Synthesis of N ⁴-acetylated 3-methylcytidine phosphoramidites for RNA solid-phase synthesis.