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Literature DB >> 28860233

Modeling mixed-lineage-rearranged leukemia initiation in CD34⁺ cells: a "CRISPR" solution.

Raúl Torres-Ruiz^1,2, Sandra Rodriguez-Perales³, Clara Bueno^2,4, Pablo Menendez^5,4,6.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28860233 PMCID： PMC5685229 DOI： 10.3324/haematol.2017.173740

Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941

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17 in total

1. Frequent chromosomal translocations induced by DNA double-strand breaks.

Authors: C Richardson; M Jasin
Journal: Nature Date: 2000-06-08 Impact factor: 49.962

2. FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.

Authors: Rene Rodriguez; Ruth Rubio; Ivan Gutierrez-Aranda; Gustavo J Melen; Carolina Elosua; Javier García-Castro; Pablo Menendez
Journal: Stem Cells Date: 2011-02 Impact factor: 6.277

3. Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.

Authors: Rene Rodriguez; Juan Tornin; Carlos Suarez; Aurora Astudillo; Ruth Rubio; Carole Yauk; Andrew Williams; Michael Rosu-Myles; Juan M Funes; Chris Boshoff; Pablo Menendez
Journal: Stem Cells Date: 2013-10 Impact factor: 6.277

Review 4. Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.

Authors: C Bueno; R Montes; P Catalina; R Rodríguez; P Menendez
Journal: Leukemia Date: 2010-12-07 Impact factor: 11.528

5. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Authors: Rosa Montes; Verónica Ayllón; Ivan Gutierrez-Aranda; Isidro Prat; M Carmen Hernández-Lamas; Laura Ponce; Silvia Bresolin; Geertruy Te Kronnie; Mel Greaves; Clara Bueno; Pablo Menendez
Journal: Blood Date: 2011-03-09 Impact factor: 22.113

Modeling mixed-lineage-rearranged leukemia initiation in CD34⁺ cells: a "CRISPR" solution.

1. Frequent chromosomal translocations induced by DNA double-strand breaks.

2. FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.

3. Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.

Review 4. Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement.

5. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

6. Spatial dynamics of chromosome translocations in living cells.

Review 7. The impact of translocations and gene fusions on cancer causation.

8. MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events.

9. Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.

10. Efficient Recreation of t(11;22) EWSR1-FLI1⁺ in Human Stem Cells Using CRISPR/Cas9.

1. The "Never-Ending" Mouse Models for MLL-Rearranged Acute Leukemia Are Still Teaching Us.