Takeshi Yamaguchi1, Hirofumi Mukai2, Futoshi Akiyama3, Koji Arihiro4, Shinobu Masuda5, Masafumi Kurosumi6, Yoshinori Kodama7, Rie Horii3, Hitoshi Tsuda8. 1. Division of Medical Oncology, Japanese Red Cross Musashino Hospital, 1-26-1, Kyonan-cho, Musashino-shi, Tokyo, 180-8610, Japan. takyamagu@musashino.jrc.or.jp. 2. Division of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan. 3. Division of Pathology, Cancer Institute of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan. 4. Department of Pathology, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. 5. Department of Pathology, Nihon University School of Medicine, 1-6, Kanda-Surugadai, Chiyoda-Ku, Tokyo, 101-8309, Japan. 6. Department of Pathology, Saitama Cancer Center, 780, Oazakomuro, Ina-machi, Kitaadachi-gun, Saitama, 362-0806, Japan. 7. Department of Pathology, National Hospital Organization Osaka National Hospital, 21-14, Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan. 8. Diagnostic Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1, Tuskiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Abstract
BACKGROUND: The degree of pathological response to neoadjuvant chemotherapy (NAC) was correlated with the prognosis in breast cancer. There are few studies published on inter-observer variability in the assessment of pathological responses among pathologists. METHODS: We collected 64 surgically resected specimens from patients who had received NAC. Three pathologists assessed the pathological responses and classified them into 7 grades according to grading system of the Japanese Breast Cancer Society. The levels of concordance among pathologists were categorized into 3 classes: full concordance (all pathologists gave the same grade), partial concordance (two of them gave the same grade), and discordance (all three gave different grades). The inter-observer agreement among pathologists was estimated using the percentage concordance and Cohen's kappa statistics. RESULTS: Full concordance, partial concordance, and discordance were seen in 28 (43%), 33 (52%), and 3 (5%) specimens, respectively. In most of partial concordance specimens (30 out of 33), the pathological response grades differed by only one level. The kappa value was 0.59. The concordance rate with regard to pCR was 97%. CONCLUSIONS: Most of the judgments among pathologists differed within one level, but there is room for improving harmonization in the assessment of pathological responses.
BACKGROUND: The degree of pathological response to neoadjuvant chemotherapy (NAC) was correlated with the prognosis in breast cancer. There are few studies published on inter-observer variability in the assessment of pathological responses among pathologists. METHODS: We collected 64 surgically resected specimens from patients who had received NAC. Three pathologists assessed the pathological responses and classified them into 7 grades according to grading system of the Japanese Breast Cancer Society. The levels of concordance among pathologists were categorized into 3 classes: full concordance (all pathologists gave the same grade), partial concordance (two of them gave the same grade), and discordance (all three gave different grades). The inter-observer agreement among pathologists was estimated using the percentage concordance and Cohen's kappa statistics. RESULTS: Full concordance, partial concordance, and discordance were seen in 28 (43%), 33 (52%), and 3 (5%) specimens, respectively. In most of partial concordance specimens (30 out of 33), the pathological response grades differed by only one level. The kappa value was 0.59. The concordance rate with regard to pCR was 97%. CONCLUSIONS: Most of the judgments among pathologists differed within one level, but there is room for improving harmonization in the assessment of pathological responses.
Authors: James A Diao; Jason K Wang; Wan Fung Chui; Andrew H Beck; Hunter L Elliott; Amaro Taylor-Weiner; Victoria Mountain; Sai Chowdary Gullapally; Ramprakash Srinivasan; Richard N Mitchell; Benjamin Glass; Sara Hoffman; Sudha K Rao; Chirag Maheshwari; Abhik Lahiri; Aaditya Prakash; Ryan McLoughlin; Jennifer K Kerner; Murray B Resnick; Michael C Montalto; Aditya Khosla; Ilan N Wapinski Journal: Nat Commun Date: 2021-03-12 Impact factor: 14.919
Authors: Noorul Wahab; Islam M Miligy; Katherine Dodd; Harvir Sahota; Michael Toss; Wenqi Lu; Mostafa Jahanifar; Mohsin Bilal; Simon Graham; Young Park; Giorgos Hadjigeorghiou; Abhir Bhalerao; Ayat G Lashen; Asmaa Y Ibrahim; Ayaka Katayama; Henry O Ebili; Matthew Parkin; Tom Sorell; Shan E Ahmed Raza; Emily Hero; Hesham Eldaly; Yee Wah Tsang; Kishore Gopalakrishnan; David Snead; Emad Rakha; Nasir Rajpoot; Fayyaz Minhas Journal: J Pathol Clin Res Date: 2022-01-10