Literature DB >> 28855731

DNA sensing in senescence.

Marina Ruiz de Galarreta1, Amaia Lujambio1,2.   

Abstract

Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

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Year:  2017        PMID： 28855731     DOI： 10.1038/ncb3603

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

1.  The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Authors:  Chanhee Kang; Qikai Xu; Timothy D Martin; Mamie Z Li; Marco Demaria; Liviu Aron; Tao Lu; Bruce A Yankner; Judith Campisi; Stephen J Elledge
Journal:  Science       Date:  2015-09-25       Impact factor: 47.728

Review 2.  Forging a signature of in vivo senescence.

Authors:  Norman E Sharpless; Charles J Sherr
Journal:  Nat Rev Cancer       Date:  2015-07       Impact factor: 60.716

Review 3.  Cellular senescence: from physiology to pathology.

Authors:  Daniel Muñoz-Espín; Manuel Serrano
Journal:  Nat Rev Mol Cell Biol       Date:  2014-07       Impact factor: 94.444

4.  cGAS is essential for the antitumor effect of immune checkpoint blockade.

Authors:  Hua Wang; Shuiqing Hu; Xiang Chen; Heping Shi; Chuo Chen; Lijun Sun; Zhijian J Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-30       Impact factor: 11.205

5.  Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

Authors:  Tae-Won Kang; Tetyana Yevsa; Norman Woller; Lisa Hoenicke; Torsten Wuestefeld; Daniel Dauch; Anja Hohmeyer; Marcus Gereke; Ramona Rudalska; Anna Potapova; Marcus Iken; Mihael Vucur; Siegfried Weiss; Mathias Heikenwalder; Sadaf Khan; Jesus Gil; Dunja Bruder; Michael Manns; Peter Schirmacher; Frank Tacke; Michael Ott; Tom Luedde; Thomas Longerich; Stefan Kubicka; Lars Zender
Journal:  Nature       Date:  2011-11-09       Impact factor: 49.962

6.  Tumour biology: senescence in premalignant tumours.

Authors:  Manuel Collado; Jesús Gil; Alejo Efeyan; Carmen Guerra; Alberto J Schuhmacher; Marta Barradas; Alberto Benguría; Angel Zaballos; Juana M Flores; Mariano Barbacid; David Beach; Manuel Serrano
Journal:  Nature       Date:  2005-08-04       Impact factor: 49.962

7.  Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

Authors:  Francis Rodier; Jean-Philippe Coppé; Christopher K Patil; Wieteke A M Hoeijmakers; Denise P Muñoz; Saba R Raza; Adam Freund; Eric Campeau; Albert R Davalos; Judith Campisi
Journal:  Nat Cell Biol       Date:  2009-07-13       Impact factor: 28.824

8.  Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Authors:  Thomas Kuilman; Chrysiis Michaloglou; Liesbeth C W Vredeveld; Sirith Douma; Remco van Doorn; Christophe J Desmet; Lucien A Aarden; Wolter J Mooi; Daniel S Peeper
Journal:  Cell       Date:  2008-06-13       Impact factor: 41.582

9.  A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Authors:  Juan Carlos Acosta; Ana Banito; Torsten Wuestefeld; Athena Georgilis; Peggy Janich; Jennifer P Morton; Dimitris Athineos; Tae-Won Kang; Felix Lasitschka; Mindaugas Andrulis; Gloria Pascual; Kelly J Morris; Sadaf Khan; Hong Jin; Gopuraja Dharmalingam; Ambrosius P Snijders; Thomas Carroll; David Capper; Catrin Pritchard; Gareth J Inman; Thomas Longerich; Owen J Sansom; Salvador Aznar Benitah; Lars Zender; Jesús Gil
Journal:  Nat Cell Biol       Date:  2013-06-16       Impact factor: 28.824

10.  Lysosome-mediated processing of chromatin in senescence.

Authors:  Andre Ivanov; Jeff Pawlikowski; Indrani Manoharan; John van Tuyn; David M Nelson; Taranjit Singh Rai; Parisha P Shah; Graeme Hewitt; Viktor I Korolchuk; Joao F Passos; Hong Wu; Shelley L Berger; Peter D Adams
Journal:  J Cell Biol       Date:  2013-07-01       Impact factor: 10.539
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  8 in total

1.  Erratum: DNA sensing in senescence.

Authors:  Marina Ruiz de Galarreta; Amaia Lujambio
Journal:  Nat Cell Biol       Date:  2017-11-29       Impact factor: 28.824

2.  NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.

Authors:  Yujun Hou; Yong Wei; Sofie Lautrup; Beimeng Yang; Yue Wang; Stephanie Cordonnier; Mark P Mattson; Deborah L Croteau; Vilhelm A Bohr
Journal:  Proc Natl Acad Sci U S A       Date:  2021-09-14       Impact factor: 12.779

3.  How Oncogenic Viruses Exploit p62-Mediated Selective Autophagy for Cancer Development.

Authors:  Shunbin Ning; Ling Wang
Journal:  Ann Immunol Immunother       Date:  2021-03-05

Review 4.  The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers.

Authors:  Shunbin Ning; Ling Wang
Journal:  Curr Cancer Drug Targets       Date:  2019       Impact factor: 3.428

5.  "Toll-free" pathways for production of type I interferons.

Authors:  Ling Wang; Shunbin Ning
Journal:  AIMS Allergy Immunol       Date:  2017-11-06

Review 6.  Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?

Authors:  Angelica Giuliani; Francesco Prattichizzo; Luigina Micolucci; Antonio Ceriello; Antonio Domenico Procopio; Maria Rita Rippo
Journal:  Mediators Inflamm       Date:  2017-12-27       Impact factor: 4.711

Review 7.  TRIMming Type I Interferon-Mediated Innate Immune Response in Antiviral and Antitumor Defense.

Authors:  Ling Wang; Shunbin Ning
Journal:  Viruses       Date:  2021-02-11       Impact factor: 5.818

8.  Cytosolic Genomic DNA functions as a Natural Antisense.

Authors:  Ken Asada; Keiya Ito; Daishi Yui; Hirokuni Tagaya; Takanori Yokota
Journal:  Sci Rep       Date:  2018-06-04       Impact factor: 4.379
  8 in total

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