| Literature DB >> 16079833 |
Manuel Collado1, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M Flores, Mariano Barbacid, David Beach, Manuel Serrano.
Abstract
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.Entities:
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Year: 2005 PMID： 16079833 DOI： 10.1038/436642a
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962