Literature DB >> 28849603

Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides.

Yuan Huang1, Kevin B Smith1, M Kevin Brown1.   

Abstract

A method for the copper-catalyzed borylacylation of activated alkenes is presented. The reaction involves borylcupration of the alkene, followed by capture of the generated alkyl-copper intermediate with an acid chloride. The reactions operated with low catalyst loading and generally occurre within 15 min at room temperature for a range of activated alkenes. In the case of vinyl arenes, enantioselective borylacylation was possible.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  acid chlorides; alkenes; boron; copper; homogeneous catalysis

Mesh：

Substances：

Year:  2017        PMID： 28849603      PMCID： PMC5708594          DOI： 10.1002/anie.201707323

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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