Corrine Hanson1, Harlan Sayles2, Erica E P A Rutten3, E F M Wouters4, William MacNee5, Peter Calverley6, Jane L Meza2, Stephen Rennard7. 1. University of Nebraska Medical Center, School of Allied Health Professions, Medical Nutrition Education, Omaha. 2. University of Nebraska Medical Center, College of Public Health, Omaha. 3. Program Development Centre, Centre of Expertise for Chronic Organ Failure,The Horn, Netherlands. 4. Department of Pulmonary Diseases, University of Maastricht, Maastrict, Netherlands. 5. University of Edinburgh, Scotland, UK. 6. Department of Medicine, Clinical Sciences Centre, University of Liverpool, UK. 7. Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
Abstract
Background: Diet is a potentially modifiable risk factor in the development and progression of many diseases, and there is evidence that diet plays a role in COPD. Objective: Evaluate the relationship between dietary intake and clinical characteristics of COPD in a large and well-characterized population of COPD patients and controls who were part of the ECLIPSE study. Methods: Limited diet records were available from 2,167 participants at 8 time points over a 3-year period. Participants reported the amount they had consumed over the last 24 hours for 8 food categories. Intake of each food group was handled as a dichotomous variable (Yes/last 24 hours at any of the 8 follow-up points vs. No at all 8 points). These 2 groups were then compared using clinical outcome measures at the last available follow-up that included lung function, emphysema, 6-minute walk, St. George's Respiratory Questionaire (SGRQ) scores, the change in these scores over a 3-year period, and inflammatory biomarkers. Multivariate models for each food group and each outcome measure were run to adjust for confounding factors of age, sex, body mass index (BMI), and smoking. Results: Participants who demonstrated recent consumption of foods associated with a healthful diet, including fish, fruit, tea, and dairy products, had greater lung function measures and less decline over time, less emphysema and emphysema progression, greater 6-minute walk and SGRQ scores, and lower levels of certain inflammatory markers. Increasing the number of diet record time points that were included in the analysis improved ability to detect significant associations. Conclusion: Diet as a possible modifiable risk factor in COPD continues to warrant investigation.
Background: Diet is a potentially modifiable risk factor in the development and progression of many diseases, and there is evidence that diet plays a role in COPD. Objective: Evaluate the relationship between dietary intake and clinical characteristics of COPD in a large and well-characterized population of COPDpatients and controls who were part of the ECLIPSE study. Methods: Limited diet records were available from 2,167 participants at 8 time points over a 3-year period. Participants reported the amount they had consumed over the last 24 hours for 8 food categories. Intake of each food group was handled as a dichotomous variable (Yes/last 24 hours at any of the 8 follow-up points vs. No at all 8 points). These 2 groups were then compared using clinical outcome measures at the last available follow-up that included lung function, emphysema, 6-minute walk, St. George's Respiratory Questionaire (SGRQ) scores, the change in these scores over a 3-year period, and inflammatory biomarkers. Multivariate models for each food group and each outcome measure were run to adjust for confounding factors of age, sex, body mass index (BMI), and smoking. Results:Participants who demonstrated recent consumption of foods associated with a healthful diet, including fish, fruit, tea, and dairy products, had greater lung function measures and less decline over time, less emphysema and emphysema progression, greater 6-minute walk and SGRQ scores, and lower levels of certain inflammatory markers. Increasing the number of diet record time points that were included in the analysis improved ability to detect significant associations. Conclusion: Diet as a possible modifiable risk factor in COPD continues to warrant investigation.
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Authors: E Shahar; A R Folsom; S L Melnick; M S Tockman; G W Comstock; V Gennaro; M W Higgins; P D Sorlie; W J Ko; M Szklo Journal: N Engl J Med Date: 1994-07-28 Impact factor: 91.245
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