BACKGROUND: There is considerable interest in the possible role of vitamin D in respiratory disease, but only one population-based study has reported associations with lung function. METHODS: The cross-sectional relationships of total dietary vitamin D intake, serum 25 hydroxy vitamin D (25(OH)D) concentrations and three vitamin D receptor (VDR) polymorphisms (Apa1, Fok1 and Cdx2) with lung function and spirometrically-defined chronic obstructive pulmonary disease (COPD) were investigated in men and women aged 59-73 years in the Hertfordshire Cohort Study, UK. RESULTS: After controlling for confounders, total vitamin D intake was positively associated with forced expiratory volume in 1 s (FEV(1); difference in FEV(1) between top and bottom quintiles of intake 0.079 l (95% CI 0.02 to 0.14), p trend=0.007, n=2942), ratio of FEV(1) to forced vital capacity (FEV(1)/FVC; p trend=0.008) and negatively associated with COPD (OR comparing top and bottom quintiles 0.57 (95% CI 0.38 to 0.87), p trend=0.02). In contrast, serum 25(OH)D concentrations were not related to FEV(1) (p trend=0.89, n=1197) but were positively associated with COPD (p trend=0.046). VDR genotypes were unrelated to lung function and did not modify the effects of dietary intake or 25(OH)D concentrations on lung function. CONCLUSIONS: The results of this study did not confirm a positive association between blood 25(OH)D concentrations and adult lung function. The apparent relationships with dietary vitamin D are likely to be explained by other highly correlated nutrients in the diet.
BACKGROUND: There is considerable interest in the possible role of vitamin D in respiratory disease, but only one population-based study has reported associations with lung function. METHODS: The cross-sectional relationships of total dietary vitamin D intake, serum 25 hydroxy vitamin D (25(OH)D) concentrations and three vitamin D receptor (VDR) polymorphisms (Apa1, Fok1 and Cdx2) with lung function and spirometrically-defined chronic obstructive pulmonary disease (COPD) were investigated in men and women aged 59-73 years in the Hertfordshire Cohort Study, UK. RESULTS: After controlling for confounders, total vitamin D intake was positively associated with forced expiratory volume in 1 s (FEV(1); difference in FEV(1) between top and bottom quintiles of intake 0.079 l (95% CI 0.02 to 0.14), p trend=0.007, n=2942), ratio of FEV(1) to forced vital capacity (FEV(1)/FVC; p trend=0.008) and negatively associated with COPD (OR comparing top and bottom quintiles 0.57 (95% CI 0.38 to 0.87), p trend=0.02). In contrast, serum 25(OH)D concentrations were not related to FEV(1) (p trend=0.89, n=1197) but were positively associated with COPD (p trend=0.046). VDR genotypes were unrelated to lung function and did not modify the effects of dietary intake or 25(OH)D concentrations on lung function. CONCLUSIONS: The results of this study did not confirm a positive association between blood 25(OH)D concentrations and adult lung function. The apparent relationships with dietary vitamin D are likely to be explained by other highly correlated nutrients in the diet.
Authors: Amy C Sims; Susan C Tilton; Vineet D Menachery; Lisa E Gralinski; Alexandra Schäfer; Melissa M Matzke; Bobbie-Jo M Webb-Robertson; Jean Chang; Maria L Luna; Casey E Long; Anil K Shukla; Armand R Bankhead; Susan E Burkett; Gregory Zornetzer; Chien-Te Kent Tseng; Thomas O Metz; Raymond Pickles; Shannon McWeeney; Richard D Smith; Michael G Katze; Katrina M Waters; Ralph S Baric Journal: J Virol Date: 2013-01-30 Impact factor: 5.103
Authors: Corrine Hanson; Harlan Sayles; Erica E P A Rutten; E F M Wouters; William MacNee; Peter Calverley; Jane L Meza; Stephen Rennard Journal: Chronic Obstr Pulm Dis Date: 2014-05-06
Authors: C van de Bool; C Mattijssen-Verdonschot; P P M J van Melick; M A Spruit; F M E Franssen; E F M Wouters; A M W J Schols; E P A Rutten Journal: Eur J Clin Nutr Date: 2013-12-11 Impact factor: 4.016
Authors: E M Dennison; D K Dhanwal; S O Shaheen; R Azagra; I Reading; K A Jameson; A A Sayer; C Cooper Journal: Arch Osteoporos Date: 2013-01-15 Impact factor: 2.617