Weronika Wojnar1, Ilona Kaczmarczyk-Sedlak2, Maria Zych2. 1. Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland. Electronic address: wwojnar@sum.edu.pl. 2. Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Abstract
BACKGROUND: Diabetic cataractogenesis is a complex process connected with hyperglycemia and oxidative stress. Free radicals induce many unfavorable changes in the activity of the antioxidative enzymes and may also lead to oxidative damage. Since diosmin, a plant-derived flavonoid, reveals antioxidative activity, the aim of the study was to investigate if this substance may counteract the oxidative stress in the lenses of diabetic rats. METHODS: The study was conducted on the male Wistar rats with streptozotocin-induced type 1 diabetes. After the administration of diosmin at the doses of 50 and 100mg/kg for 4 weeks the oxidative stress markers in the lenses of these rats were evaluated. Tested markers included: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, advanced oxidation protein products and malonyldialdehyde. RESULTS: The obtained results indicate that the administration of diosmin to the diabetic rats counteracted the unfavorable changes induced by diabetes in the lenses. CONCLUSION: It can be assumed that diosmin may be a promising compound in prevention or delaying the cataract formation during diabetes.
BACKGROUND:Diabetic cataractogenesis is a complex process connected with hyperglycemia and oxidative stress. Free radicals induce many unfavorable changes in the activity of the antioxidative enzymes and may also lead to oxidative damage. Since diosmin, a plant-derived flavonoid, reveals antioxidative activity, the aim of the study was to investigate if this substance may counteract the oxidative stress in the lenses of diabeticrats. METHODS: The study was conducted on the male Wistar rats with streptozotocin-induced type 1 diabetes. After the administration of diosmin at the doses of 50 and 100mg/kg for 4 weeks the oxidative stress markers in the lenses of these rats were evaluated. Tested markers included: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, advanced oxidation protein products and malonyldialdehyde. RESULTS: The obtained results indicate that the administration of diosmin to the diabeticrats counteracted the unfavorable changes induced by diabetes in the lenses. CONCLUSION: It can be assumed that diosmin may be a promising compound in prevention or delaying the cataract formation during diabetes.
Authors: Abdelazim E Elhelaly; Gadah AlBasher; Saleh Alfarraj; Rafa Almeer; Eshak I Bahbah; Maged M A Fouda; Simona G Bungău; Lotfi Aleya; Mohamed M Abdel-Daim Journal: Environ Sci Pollut Res Int Date: 2019-11-04 Impact factor: 4.223
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