Literature DB >> 2883998

Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus.

L M Kemp, P M Brickell, N B La Thangue, D S Latchman.   

Abstract

Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.

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Year:  1986        PMID: 2883998     DOI: 10.1007/bf01114970

Source DB:  PubMed          Journal:  Biosci Rep        ISSN: 0144-8463            Impact factor:   3.840


  10 in total

1.  The herpes simplex virus virion protein Vmw65 transcriptionally activates the gene encoding the U4 snRNA but not that encoding the U2 snRNA during lytic infection.

Authors:  D S Latchman
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

2.  The different competitive abilities of viral TAATGARAT elements and cellular octamer motifs, mediate the induction of viral immediate-early genes and the repression of the histone H2B gene in herpes simplex virus infected cells.

Authors:  D S Latchman; J F Partidge; J K Estridge; L M Kemp
Journal:  Nucleic Acids Res       Date:  1989-11-11       Impact factor: 16.971

3.  Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.

Authors:  D S Latchman; J K Estridge; L M Kemp
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

4.  The herpes simplex virus protein Vmw65 can trans-activate both viral and cellular promoters in neuronal cells.

Authors:  J K Estridge; L M Kemp; D S Latchman
Journal:  Biochem J       Date:  1990-10-01       Impact factor: 3.857

5.  Human topoisomerase 1 messenger RNA is not destabilized by the herpes simplex virus type 2 virion-associated shut-off function.

Authors:  K F Bastow; B S Zhou; Y C Cheng
Journal:  Virus Genes       Date:  1989-08       Impact factor: 2.332

6.  Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.

Authors:  K L Jang; B Pulverer; J R Woodgett; D S Latchman
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

7.  Elevation of heat shock protein synthesis and hsp gene transcription during monocyte to macrophage differentiation of U937 cells.

Authors:  B M Twomey; S McCallum; D A Isenberg; D S Latchman
Journal:  Clin Exp Immunol       Date:  1993-08       Impact factor: 4.330

8.  The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.

Authors:  K L Jang; D S Latchman
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

9.  Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor.

Authors:  K A Lillycrop; M K Howard; J K Estridge; D S Latchman
Journal:  Nucleic Acids Res       Date:  1994-03-11       Impact factor: 16.971

10.  Differential regulation of octamer-containing cellular genes by the herpes simplex virus virion protein Vmw65 is mediated by sequence differences in the octamer element.

Authors:  L M Kemp; D S Latchman
Journal:  EMBO J       Date:  1988-12-20       Impact factor: 11.598

  10 in total

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