| Literature DB >> 28838171 |
Stephanie Shendale1, Margaret Farrell2, Lee M Hampton3, Jennifer B Harris3, Tasleem Kachra4, Feyrouz Kurji5, Manish Patel6, Alejandro Ramirez Gonzalez1, Simona Zipursky4,7.
Abstract
The global switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV) ("the switch") presented an unprecedented challenge to countries. In order to mitigate the risks associated with country-level delays in implementing the switch, the Global Polio Eradication Initiative provided catalytic financial support to specific countries for operational costs unique to the switch. Between November 2015 and February 2016, a total of approximately US$19.4 million in financial support was provided to 67 countries. On average, country budgets allocated 20% to human resources, 23% to trainings and meetings, 8% to communications and advocacy, 9% to logistics, 15% to monitoring, and 5% to waste management. All 67 funded countries successfully switched from tOPV to bOPV during April-May 2016. This funding provided target countries with the necessary catalytic support to facilitate the execution of the switch on an accelerated timeline, and the mechanism offers a model for similar support to future global health efforts, such as the eventual global withdrawal of bOPV.Entities:
Keywords: OPV; bivalent OPV; finance; oral polio vaccine; polio; trivalent OPV
Mesh:
Substances:
Year: 2017 PMID: 28838171 PMCID: PMC5853345 DOI: 10.1093/infdis/jiw577
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226
Main Cost Drivers Assumed in the Model
| Budget Category | Average Share of Budget (%) | Main Activities Included |
|---|---|---|
| Human resources | 43% | Switch coordinators, supervisors and switch teams |
| Document production | 3% | Development of training materials |
| Trainings and meetings | 9% | Training of medical staff |
| Communication and advocacy | 7% | Sensitization activities |
| Logistics | 1% | tOPV inventories |
| Transport for implementation and supervision | 14% | Vehicle and motorbike rentals |
| Monitoring | 17%a | Switch monitors, supervisors and coordinators |
| Waste management | 1% | Return of tOPV to disposal sites |
| Miscellaneous | 5% | … |
| Total | 100% | … |
Abbreviations: bOPV, bivalent oral polio vaccine; ICC, Interagency Coordinating Committee; NCC, National Certification Committee; tOPV, trivalent oral polio vaccine.
aMonitoring activities were expected to account for approximately 15% of overall costs in low-risk countries, and 18%–20% for higher-risk countries where additional monitoring was anticipated.
Country Categorization for Budget Estimation
| VDPV RiskOperational Cost | Low Risk for cVDPV2 | High Risk for cVDPV2 |
|---|---|---|
| Low | Bangladesh, Benin, Burkina Faso, Cambodia, Congo, Cote d’Ivoire, Egypt, Haiti, Indonesia, Laos, Liberia, Mali, Myanmar, Nepal, Papua New Guinea, Philippines, Senegal, Tajikistan, Timor-Leste |
|
| High | Burundi, Central African Republic, Eritrea, Guinea Bissau, Mauritania, Mozambique, Sierra Leone, Sudan, Uganda |
|
| Low support | High support |
Note: Countries in bold are those with a large GPEI-funded workforce.
Abbreviations: cVDPV2, type 2 circulating vaccine-derived polioviruses; GPEI, Global Polio Eradication Initiative; VDPV, vaccine-derived polioviruses.
Operational Cost (US$)/10 Million Population
| VDPV Risk | Low Risk for cVDPV2 | High Risk for cVDPV2 | Countries With Large GPEI Workforces, High Risk |
|---|---|---|---|
| Low | 126316 | 157767 | 36857 |
| High | 193199 | 230764 | 55957 |
| Low support | High support | Reduced support |
Abbreviations: cVDPV2, type 2 circulating vaccine-derived polioviruses; GPEI, Global Polio Eradication Initiative; VDPV, vaccine-derived polioviruses.
Percentage of Total National Switch Budgets Supported by GPEI
|
| 25 countries |
|
| 22 countries |
|
| 12 countries |
|
| 3 countries |
Note: Total national budgets were only received for 62 countries.
Abbreviation: GPEI, Global Polio Eradication Initiative.
Financial Support Requested and Provided, as Compared to the Model-Generated Estimated Budgets
| Country Request vs Estimated Envelope | GPEI Support Provided vs Estimated Envelope | GPEI Support Provided vs Amount Requested | |
|---|---|---|---|
| Greater than | 35 (52%) | 23 (34%) | 2 (3%) |
| Less than | 32 (48%) | 33 (49%) | 38 (57%) |
| Equal to | … | 11 (17%) | 27 (40%) |
Abbreviation: GPEI, Global Polio Eradication Initiative.
Figure 1.Approximate budget breakdowns, model, and actual (average, based on sample of budgets reviewed).
Summary Table of Switch Financial Support and Review Process
| Total GPEI funding envelope available | US$23715722 |
| Total GPEI funding provided | US$19370288 |
| Eligibility criteria | GPEI financial switch support was made available to all LICs and LMICs falling within Tiers 1, 2, and 3 (based on risk of a type 2 polio outbreak following the switch). |
| Countries eligible for support | 43 |
| Additional countries supported | 24 |
| Time frame for application and review | Deadline for applications was 13 November 2015; however, applications continued to arrive until mid-December. First round of reviews took place between mid-November and mid-January. Additional country applications were then received, and reviews continued until mid-March. |
| Application requirements | Countries were required to submit: |
| Review process | 1) Complete application packages were received and vetted by the WHO and UNICEF regional offices. |
Abbreviations: GPEI, Global Polio Eradication Initiative; ICC, Interagency Coordinating Committee; IMG, Immunization Systems Management Group; LICs, low-income countries; LMICs, lower-middle-income countries; MOH, Ministry of Health; Review Group, Switch Country Financial Support Review Group; tOPV, trivalent oral polio vaccine; UNICEF, United Nations Children’s Fund; WHO, World Health Organization.
| Original List of Eligible Countries | Additional Countries Supported |
|---|---|
| Afghanistan | China |
| Bangladesh | Cook Islands |
| Benin | Dominican Republic |
| Burkina Faso | Democratic People’s Republic of Korea |
| Burundi | Gabon |
| Cambodia | Gambia |
| Cameroon | Ghana |
| Central African Republic (the) | Honduras |
| Chad | Jordan |
| Congo (the) | Kiribati |
| Cote d’Ivoire | Libya |
| Democratic Republic of Congo | Malawi |
| Egypt | Maldives |
| Eritrea | Mongolia |
| Ethiopia | Nauru |
| Guinea | Nicaragua |
| Guinea-Bissau | Samoa |
| Haiti | Sao Tome and Principe |
| India | Tanzania (United Republic of) |
| Indonesia | Togo |
| Kenya | Tonga |
| Lao PDR | Tunisia |
| Liberia | Vanuatu |
| Madagascar | Zimbabwe |
| Mali | … |
| Mauritania | … |
| Mozambique | … |
| Myanmar | … |
| Nepal | … |
| Niger (the) | … |
| Nigeria | … |
| Pakistan | … |
| Papua New Guinea | … |
| Philippines (the) | … |
| Senegal | … |
| Sierra Leone | … |
| Somalia | … |
| South Sudan | … |
| Sudan (the) | … |
| Tajikistan | … |
| Timor-Leste | … |
| Uganda | … |
| Yemen | … |
| No. | Budget Category | Activity | Average Share of Total Budget |
|---|---|---|---|
|
|
|
| |
| 1.1 | Development of training materials | ||
| 1.2 | Printing of training and monitoring materials | ||
| 1.3 | Printing of information materials | ||
|
|
|
| |
| 2.1 | Switch Support Team coordinator | ||
| 2.2 | Switch Support Team at regional level | ||
| 2.3 | Cold chain assistants | ||
| 2.4 | Data manager | ||
| 2.5 | Regional supervision MOH | ||
| 2.6 | District supervision MOH | ||
| 2.7 | National MOH supervisor | ||
| 2.8 | National MOH supervisor, driver | ||
|
|
|
| |
| 3.1 | tOPV inventories | ||
| 3.2 | Distribution of bOPV to districts | ||
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| |
| 4.1 | Plan written with support of national SST | ||
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| |
| 5.1 | Information meeting at national and regional levels | ||
| 5.2 | Information meeting with all service providers at district level | ||
| 5.3 | Meetings with special groups, private sector | ||
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| |
| 6.1 | ICC meetings | ||
| 6.2 | NCC meetings | ||
| 6.3 | Switch Support Team national level training | ||
| 6.4 | Switch Support Team regional training | ||
| 6.5 | Training medical staff | ||
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|
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| |
| 7.1 | Switch Support Team coordinator, fuel | ||
| 7.2 | Switch Support Team coordinator, rented car | ||
| 7.3 | Switch Support Team, regional, motorbike, fuel | ||
| 7.4 | Regional supervision, own car, fuel | ||
| 7.5 | District supervision, own motorbike, fuel | ||
| 7.6 | National supervision, rented car | ||
| 7.7 | National supervisor, fuel | ||
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| |
| 8.1 | Switch Monitoring national coordinator | ||
| 8.2 | Switch Monitoring regional supervisors | ||
| 8.3 | Switch Monitors | ||
| 8.4 | Training Switch Monitors | ||
| 8.5 | Switch Monitoring national coordinator, rented car | ||
| 8.6 | Switch Monitoring national coordinator, fuel | ||
| 8.7 | Switch Monitoring regional supervisor, fuel | ||
| 8.8 | Switch Monitoring regional supervisor, rented motorbike | ||
| 8.9 | Switch Monitors, fuel | ||
| 8.10 | Switch Monitors, rented motorbikes | ||
| 8.11 | Additional monitoring expenses for follow-up of problem areas | ||
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| 9.1 | Selection of disposal sites | ||
| 9.2 | Disposal sites preparation | ||
| 9.3 | Return of tOPV to the disposal site | ||
| 9.4 | Disposal | ||
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| |
Abbreviations: bOPV, bivalent oral polio vaccine; ICC, Interagency Coordinating Committee; MOH, Ministry of Health; NCC, National Certification Committee; tOPV, trivalent oral polio vaccine.
aMonitoring costs were estimated to account for 15% in low-risk countries and 18%–20% in higher-risk countries where additional monitoring was anticipated.