| Literature DB >> 28835638 |
Qiao Fan1, Chui Ming Gemmy Cheung2,3, Li Jia Chen4, Kenji Yamashiro5, Jeeyun Ahn6, Augustinus Laude7, Ranjana Mathur2,3, Chan Choi Mun2, Ian Y Yeo2, Tock Han Lim7, Yik-Ying Teo8,9,10, Chiea Chuen Khor2,10, Kyu-Hyung Park6, Nagahisa Yoshimura5, Chi Pui Pang4, Tien Yin Wong2,3,11, Ching-Yu Cheng2,3,11.
Abstract
Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD) more frequently seen in East Asians, has both common and distinct clinical manifestations with typical neovascular AMD (tAMD). We aim to examine the extent to which common genetic variants are shared between these two subtypes. We performed the meta-analysis of association in a total of 1062 PCV patients, 1157 tAMD patients and 5275 controls of East Asian descent from the Genetics of AMD in Asians Consortium at the 34 known AMD loci. A total of eight loci were significantly associated with PCV, including age-related maculopathy susceptibility 2 (ARMS2)-HtrA serine peptidase 1 (HTRA1), complement factor H (CFH), C2-CFB-SKIV2L, CETP, VEGFA, ADAMTS9-AS2 and TGFBR1 (P<5 × 10-4) from the single-nucleotide polymorphism-based test and COL4A3 from the gene-based tests (Pgene=2.02 × 10-4). PCV and tAMD are genetically highly correlated (rg=0.69, P=4.68 × 10-3), with AMD known loci accounting for up to 36% variation. Weaker association for PCV was observed at ARMS2-HTRA1 (Pdif=4.39 × 10-4) and KMT2E-SRPK2(Pdif=4.43 × 10-3), compared with tAMD. Variants at CFH, CETP and VEGFA exhibited different association signals in East Asians, in contrast to those in European individuals. Our data suggest a substantially shared genetic susceptibility for PCV and tAMD, while also highlight the unique associations for PCV, which is useful in understanding the pathogenesis of PCV.Entities:
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Year: 2017 PMID： 28835638 DOI： 10.1038/jhg.2017.83
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172