Literature DB >> 28833549

Regression of diffuse B-cell lymphoma of the leg with intralesional gentian violet.

Shikha Rao1, Robert Morris1, Zakiya P Rice1, Jack L Arbiser1.   

Abstract

In this case report, a patient of primary cutaneous diffuse B-cell lymphoma, leg type was treated with intralesional gentian violet as she was judged to be too medically fragile for conventional chemotherapy due to advanced age and multiple serious comorbidities. Gentian violet (crystal violet/hexamethyl pararosaniline) is a triphenylmethane dye. It has been shown to have an inhibitory effect on NADPH oxidase, an enzyme family which is found in abundance in reactive oxygen-driven tumors such as melanoma and lymphoma. We hypothesize that intralesional gentian violet treatment caused signalling changes in the lymphoma which allowed for immune clearance of the lymphoma. Complete resolution of the patient's lesion was noted on a follow-up visit.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Diffuse B-cell lymphoma; NADPH oxidases; gentian violet

Mesh：

Substances：

Year:  2017        PMID： 28833549      PMCID： PMC5925423          DOI： 10.1111/exd.13418

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  9 in total

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Journal:  Blood       Date:  2014-10-30       Impact factor: 22.113

Review 2.  Gentian violet: a 19th century drug re-emerges in the 21st century.

Authors:  Alexander M Maley; Jack L Arbiser
Journal:  Exp Dermatol       Date:  2013-12       Impact factor: 3.960

3.  Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.

Authors:  Qiang Li; Maged M Harraz; Weihong Zhou; Liang N Zhang; Wei Ding; Yulong Zhang; Tim Eggleston; Charles Yeaman; Botond Banfi; John F Engelhardt
Journal:  Mol Cell Biol       Date:  2006-01       Impact factor: 4.272

4.  Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.

Authors:  Jennifer M Munson; Levi Fried; Sydney A Rowson; Michael Y Bonner; Lohitash Karumbaiah; Begoña Diaz; Sara A Courtneidge; Ulla G Knaus; Daniel J Brat; Jack L Arbiser; Ravi V Bellamkonda
Journal:  Sci Transl Med       Date:  2012-03-28       Impact factor: 17.956

Review 5.  The metabolism and mode of action of gentian violet.

Authors:  R Docampo; S N Moreno
Journal:  Drug Metab Rev       Date:  1990       Impact factor: 4.518

6.  Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.

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Journal:  J Invest Dermatol       Date:  2006-06-01       Impact factor: 8.551

7.  Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival.

Authors:  Silvia Pietrobono; Andrea Morandi; Sinforosa Gagliardi; Gianni Gerlini; Lorenzo Borgognoni; Paola Chiarugi; Jack L Arbiser; Barbara Stecca
Journal:  J Invest Dermatol       Date:  2016-06-29       Impact factor: 8.551

Review 8.  Targeting NADPH oxidases for the treatment of cancer and inflammation.

Authors:  Michael Y Bonner; Jack L Arbiser
Journal:  Cell Mol Life Sci       Date:  2012-05-13       Impact factor: 9.261

9.  Immunosuppression may be present within condyloma acuminata.

Authors:  Caroline Le Poole; Cecele J Denman; Jack L Arbiser
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  9 in total
  4 in total

1.  Gentian violet induces apoptosis and ferroptosis via modulating p53 and MDM2 in hepatocellular carcinoma.

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Journal:  Am J Cancer Res       Date:  2022-07-15       Impact factor: 5.942

2.  Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro Study.

Authors:  Jianqiang Wu; Gary S Wood
Journal:  JAMA Dermatol       Date:  2018-10-01       Impact factor: 10.282

3.  Induction of remission in a patient with end-stage cutaneous T-cell lymphoma by concurrent use of radiation therapy, gentian violet, and mogamulizumab.

Authors:  Sarah A Westergaard; Mary Jo Lechowicz; Maggie Harrington; Justin Elsey; Jack L Arbiser; Mohammad K Khan
Journal:  JAAD Case Rep       Date:  2020-06-04

Review 4.  Reuse of Molecules for Glioblastoma Therapy.

Authors:  Abigail Koehler; Aniruddha Karve; Pankaj Desai; Jack Arbiser; David R Plas; Xiaoyang Qi; Renee D Read; Atsuo T Sasaki; Vaibhavkumar S Gawali; Donatien K Toukam; Debanjan Bhattacharya; Laura Kallay; Daniel A Pomeranz Krummel; Soma Sengupta
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-28
  4 in total

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