Maria Vittoria Micioni Di Bonaventura1, Massimo Ubaldi1, Maria Elena Giusepponi1, Kenner C Rice2, Maurizio Massi1, Roberto Ciccocioppo1, Carlo Cifani1. 1. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy. 2. Department of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, Maryland.
Abstract
OBJECTIVE: The present study evaluated the effect of systemic injection of the CRF1 receptor antagonist R121919, the corticosterone synthesis inhibitor metyrapone and central amygdala (CeA) injections of the nonselective CRF antagonist D-Phe-CRF(12-41) in rats in which binge eating was evoked by stress and cycles of food restriction. METHOD: Female rats were subjected or not to repeated cycles of regular chow food restriction/ad libitum feeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 min without allowing access, before assessing food consumption. RESULTS: Systemic injections of R121919, but not of the metyrapone, blocked binge-like eating behavior. Restricted and stressed rats showed up-regulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis and CeA but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection D-Phe-CRF(12-41) in CeA but not in the BLA-blocked binge-like eating behavior. DISCUSSION: These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating and the crucial role of CRF receptors in CeA. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.
OBJECTIVE: The present study evaluated the effect of systemic injection of the CRF1 receptor antagonist R121919, the corticosterone synthesis inhibitor metyrapone and central amygdala (CeA) injections of the nonselective CRF antagonist D-Phe-CRF(12-41) in rats in which binge eating was evoked by stress and cycles of food restriction. METHOD: Female rats were subjected or not to repeated cycles of regular chow food restriction/ad libitum feeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 min without allowing access, before assessing food consumption. RESULTS: Systemic injections of R121919, but not of the metyrapone, blocked binge-like eating behavior. Restricted and stressed rats showed up-regulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis and CeA but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection D-Phe-CRF(12-41) in CeA but not in the BLA-blocked binge-like eating behavior. DISCUSSION: These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating and the crucial role of CRF receptors in CeA. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.
Authors: Lixin Wang; Miriam Goebel-Stengel; Andreas Stengel; S Vincent Wu; Gordon Ohning; Yvette Taché Journal: Brain Res Date: 2011-07-23 Impact factor: 3.252
Authors: Maria Vittoria Micioni Di Bonaventura; Thomas A Lutz; Adele Romano; Mariangela Pucci; Nori Geary; Lori Asarian; Carlo Cifani Journal: Int J Eat Disord Date: 2017-02-23 Impact factor: 4.861
Authors: Laura Piccoli; Maria Vittoria Micioni Di Bonaventura; Carlo Cifani; Vivian J A Costantini; Mario Massagrande; Dino Montanari; Prisca Martinelli; Marinella Antolini; Roberto Ciccocioppo; Maurizio Massi; Emilio Merlo-Pich; Romano Di Fabio; Mauro Corsi Journal: Neuropsychopharmacology Date: 2012-05-09 Impact factor: 7.853
Authors: Adele Romano; Maria Vittoria Micioni Di Bonaventura; Cristina Anna Gallelli; Justyna Barbara Koczwara; Dorien Smeets; Maria Elena Giusepponi; Marialuisa De Ceglia; Marzia Friuli; Emanuela Micioni Di Bonaventura; Caterina Scuderi; Annabella Vitalone; Antonella Tramutola; Fabio Altieri; Thomas A Lutz; Anna Maria Giudetti; Tommaso Cassano; Carlo Cifani; Silvana Gaetani Journal: Neuropsychopharmacology Date: 2020-04-30 Impact factor: 7.853
Authors: Luca Botticelli; Emanuela Micioni Di Bonaventura; Massimo Ubaldi; Roberto Ciccocioppo; Carlo Cifani; Maria Vittoria Micioni Di Bonaventura Journal: Pharmaceuticals (Basel) Date: 2021-03-26
Authors: Alan Kania; Agata Szlaga; Patryk Sambak; Anna Gugula; Ewa Blasiak; Maria Vittoria Micioni Di Bonaventura; Mohammad Akhter Hossain; Carlo Cifani; Grzegorz Hess; Andrew L Gundlach; Anna Blasiak Journal: J Neurosci Date: 2020-06-12 Impact factor: 6.167