Ricardo Gaspar1, Luís Abegão Pinto2, David Cordeiro Sousa2. 1. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. 2. Vision Sciences Study Center, Faculdade de Medicina, Universidade de Lisboa, Portugal.
Abstract
PURPOSE: Studies have suggested that corneal biomechanical properties influence intraocular pressure (IOP) measurements, namely central corneal thickness (CCT) and corneal hysteresis (CH). The present study aimed to investigate the associations of CH and CCT with glaucoma development. METHODS: We performed a review of the literature and meta-analysis of observational studies (2006-2016) that included both adult glaucoma patients and controls and reported CCT and CH as outcomes. Nineteen studies were conside red eligible, and the mean difference (MD) between groups (patient and control) for both variables was used for statistical analyses. RESULTS: A total of 1,213 glaucoma and 1,055 healthy eyes were studied. Quan titative analysis suggested that CH was significantly lower in the glaucoma group than in the control group (MD=-1.54 mmHg, 95% CI [-1.68, -1.41], P<0.0001). Additionally, CCT was significantly lower in the glaucoma group than in the control group (MD=-8.49 µm, 95% CI [-11.36, -5.62], P<0.001). CONCLUSION: Corneal properties appear to differ between glaucoma patients and healthy controls. Our results emphasize the importance of corneal biomechanical properties in IOP interpretation and should support further studies on the influence of CH and CCT in glaucoma screening and diagnosis.
PURPOSE: Studies have suggested that corneal biomechanical properties influence intraocular pressure (IOP) measurements, namely central corneal thickness (CCT) and corneal hysteresis (CH). The present study aimed to investigate the associations of CH and CCT with glaucoma development. METHODS: We performed a review of the literature and meta-analysis of observational studies (2006-2016) that included both adult glaucomapatients and controls and reported CCT and CH as outcomes. Nineteen studies were conside red eligible, and the mean difference (MD) between groups (patient and control) for both variables was used for statistical analyses. RESULTS: A total of 1,213 glaucoma and 1,055 healthy eyes were studied. Quan titative analysis suggested that CH was significantly lower in the glaucoma group than in the control group (MD=-1.54 mmHg, 95% CI [-1.68, -1.41], P<0.0001). Additionally, CCT was significantly lower in the glaucoma group than in the control group (MD=-8.49 µm, 95% CI [-11.36, -5.62], P<0.001). CONCLUSION: Corneal properties appear to differ between glaucomapatients and healthy controls. Our results emphasize the importance of corneal biomechanical properties in IOP interpretation and should support further studies on the influence of CH and CCT in glaucoma screening and diagnosis.
Authors: Esther M Hoffmann; Fidan Aghayeva; Felix M Wagner; Achim Fiess; Markus Nagler; Thomas Münzel; Philipp S Wild; Manfred E Beutel; Irene Schmidtmann; Karl J Lackner; Norbert Pfeiffer; Alexander K Schuster Journal: Invest Ophthalmol Vis Sci Date: 2022-01-03 Impact factor: 4.799