Literature DB >> 2883086

Analysis of the human apolipoprotein B gene; complete structure of the B-74 region.

P Carlsson, C Darnfors, S O Olofsson, G Bjursell.   

Abstract

In this paper we describe the nucleotide sequence of the B-74 region of human apolipoprotein B-100 mRNA. This region comprises the 3'-proximal three-quarters of the mRNA and contains 10,089 nucleotides (nt), 9786 of which are coding. Combining our data with the published sequence of the 5'-proximal one-quarter (i.e., the B-26 region [Protter et al., Proc. Natl. Acad. Sci. USA 83 (1986) 5678-5682] assigns 14,059 nt to the apoB-100 mRNA. The coding sequence spans 13,548 nt or 4516 amino acids (leader peptide excluded). The B-74 part of the apoB gene is built up of five exons separated by small introns, and is dominated by an unusually large exon of 7.5 kb. The derivation of two (EcoRI and XbaI) restriction fragment length polymorphisms occurring in the coding region is discussed.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2883086     DOI： 10.1016/0378-1119(86)90383-5

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

1.  The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.

Authors:  M Jacob; H Gallinaro
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

2.  Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.

Authors:  T Demant; R S Houlston; M J Caslake; J J Series; J Shepherd; C J Packard; S E Humphries
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

3.  Similarity landscapes: a way to detect many structural and sequence motifs in both introns and exons.

Authors:  M Hultner; D W Smith; C Wills
Journal:  J Mol Evol       Date:  1994-02       Impact factor: 2.395

4.  Genetic polymorphism of the apolipoprotein B gene locus influences serum LDL cholesterol level in familial hypercholesterolemia.

Authors:  K Aalto-Setälä; H Gylling; E Helve; P Kovanen; T A Miettinen; H Turtola; K Kontula
Journal:  Hum Genet       Date:  1989-07       Impact factor: 4.132

5.  Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

Authors:  L F Soria; E H Ludwig; H R Clarke; G L Vega; S M Grundy; B J McCarthy
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

6.  RNA editing: a novel mechanism for regulating lipid transport from the intestine.

Authors:  J Scott; S C Wallis; M S Davies; J K Wynne; L M Powell; D M Driscoll
Journal:  Gut       Date:  1989-11       Impact factor: 23.059

7.  Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3' end of the human gene.

Authors:  A M Dunning; H H Renges; C F Xu; R Peacock; R Brasseur; G Laxer; M J Tikkanen; R Bütler; N Saha; A Hamsten
Journal:  Am J Hum Genet       Date:  1992-01       Impact factor: 11.025

8.  Relationships between DNA and protein polymorphisms of apolipoprotein B.

Authors:  A M Dunning; M J Tikkanen; C Ehnholm; R Bütler; S E Humphries
Journal:  Hum Genet       Date:  1988-04       Impact factor: 4.132

9.  Extracoronary atherosclerosis and genetic variants of apolipoprotein AI-CIII cluster in myocardial infarction survivors from southern Italy.

Authors:  F De Lorenzo; A Monticelli; S Cocozza; B De Simone; P Rubba
Journal:  Clin Investig       Date:  1994-06

10.  Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer.

Authors:  Mahendra Kumar Singh; Udai Bhan Pandey; Uday Chand Ghoshal; Itha Srivenu; Vinay Kumar Kapoor; Gourdas Choudhuri; Balraj Mittal
Journal:  Hum Genet       Date:  2003-11-14       Impact factor: 4.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.