Kenji Takahashi1,2,3, Sanshiro Hashimoto4, Shinji Kiuchi2, Atsuya Watanabe5, Hiroshi Nakamura6, Futoshi Ikuta1, Tomoyuki Okuaki7, Tatsunori Kataoka1, Tokifumi Majima1, Shinro Takai1. 1. a Department of Orthopaedic Surgery , Nippon Medical School , Tokyo , Japan. 2. b AIC Yaesu Clinic , Tokyo , Japan. 3. c Department of Orthopaedic Surgery, Graduate School of Medical Science , International University of Health and Welfare , Tochigi , Japan. 4. d Minami-Shinjuku Orthopaedic Rehabilitation Clinic , Tokyo , Japan. 5. e Department of General Medical Services, Graduate School of Medicine , Chiba University , Chiba , Japan. 6. f Department of Orthopaedic Surgery , Sanno Hospital , Tokyo , Japan. 7. g Philips Healthcare, MR Clinical Science , Tokyo , Japan.
Abstract
OBJECTIVES: Morphological features of the distal femur and proximal tibia associated with cartilage degeneration are unknown. This study aimed to elucidate local anatomical parameters of the knee which correlate with articular cartilage degeneration using MRI T1ρ mapping. METHODS: This study involved 200 subjects with knee pain (mean age, 48.7 years; range, 14-80 years) with no severe osteoarthritic changes on plain X-ray. T1ρ values were measured in the regions of interest on the surface layer of the cartilage on mid-coronal images of the femorotibial joint. Assessment of medial and lateral posterior tibial slope (MTS, LTS) and medial and lateral femoral condylar offset ratio (MFCOR, LFCOR) was performed using sagittal proton density-weighted imaging. Morphological assessment of posterior root and horn of menisci was also performed according to a modified Whole Organ Magnetic Resonance Imaging Score (WORMS) of the knee. RESULTS: Multiple regression analysis revealed that a decrease in MTS was associated with increased T1ρ values in the medial tibia, independent of age, osteoarthritic changes on plain X-ray, femur-tibia angle (FTA), and posterior medial meniscal lesions. CONCLUSIONS: Shallow MTS correlates with cartilage degeneration in symptomatic patients. This parameter could help in understanding the etiology of osteoarthritis in the early stage. Future kinematic studies will be needed to confirm our findings.
OBJECTIVES: Morphological features of the distal femur and proximal tibia associated with cartilage degeneration are unknown. This study aimed to elucidate local anatomical parameters of the knee which correlate with articular cartilage degeneration using MRI T1ρ mapping. METHODS: This study involved 200 subjects with knee pain (mean age, 48.7 years; range, 14-80 years) with no severe osteoarthritic changes on plain X-ray. T1ρ values were measured in the regions of interest on the surface layer of the cartilage on mid-coronal images of the femorotibial joint. Assessment of medial and lateral posterior tibial slope (MTS, LTS) and medial and lateral femoral condylar offset ratio (MFCOR, LFCOR) was performed using sagittal proton density-weighted imaging. Morphological assessment of posterior root and horn of menisci was also performed according to a modified Whole Organ Magnetic Resonance Imaging Score (WORMS) of the knee. RESULTS: Multiple regression analysis revealed that a decrease in MTS was associated with increased T1ρ values in the medial tibia, independent of age, osteoarthritic changes on plain X-ray, femur-tibia angle (FTA), and posterior medial meniscal lesions. CONCLUSIONS: Shallow MTS correlates with cartilage degeneration in symptomatic patients. This parameter could help in understanding the etiology of osteoarthritis in the early stage. Future kinematic studies will be needed to confirm our findings.
Authors: Tzu-Chieh Liao; Hannah Jergas; Radhika Tibrewala; Emma Bahroos; Thomas M Link; Sharmila Majumdar; Richard B Souza; Valentina Pedoia Journal: J Orthop Res Date: 2020-10-05 Impact factor: 3.102
Authors: Ryan Jahn; Joseph D Cooper; Tristan Juhan; Hyunwoo P Kang; Ioanna K Bolia; Seth C Gamradt; George F Hatch; Alexander E Weber Journal: Orthop J Sports Med Date: 2021-10-07