Literature DB >> 28827150

The role of the leukemia inhibitory factor receptor in neuroprotective signaling.

Stephanie M Davis1, Keith R Pennypacker2.   

Abstract

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190kDa subunit couples with the 130kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.
Copyright © 2017. Published by Elsevier Inc.

Entities:  

Keywords:  Brain injury; Cytokine; Inflammation; Signal transduction

Mesh：

Substances：

Year:  2017        PMID： 28827150      PMCID： PMC6265657          DOI： 10.1016/j.pharmthera.2017.08.008

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  116 in total

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2.  Neurotrophic effects of leukemia inhibitory factor on neural cells derived from human embryonic stem cells.

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4.  Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.

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Review 2.  The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: Potential treatments for encephalopathy of prematurity.

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