Literature DB >> 12915243

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis.

Michael F Azari1, Elizabeth C Lopes, Chantelle Stubna, Bradley J Turner, Dawei Zang, Nicos A Nicola, John B Kurek, Surindar S Cheema.   

Abstract

We investigated the anatomical and behavioural effects of daily intraperitoneal injection of 25 microg/kg of LIF in the SOD1(G93A G1H) mouse model of familial ALS. We found some subtle beneficial behavioural changes in LIF treated mice. These included later onset of clinical disease in females as determined by clinical scoring; better grip strength in males; and delayed development of motor impairment in males as determined by the rotarod test. However, we found no significant rescue of motoneurons or prolongation of survival as a result of this systemic dose of LIF in these mice.

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Year:  2003        PMID： 12915243     DOI： 10.1016/s0006-8993(03)02989-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  SOD1-G93A mice exhibit muscle-fiber-type-specific decreases in glucose uptake in the absence of whole-body changes in metabolism.

Authors:  Susan E Smittkamp; Jill K Morris; Gregory L Bomhoff; Mark E Chertoff; Paige C Geiger; John A Stanford
Journal:  Neurodegener Dis       Date:  2013-09-06       Impact factor: 2.977

2.  Identification of early disease progression in an ALS rat model.

Authors:  Jason R Thonhoff; Paivi M Jordan; Joseph R Karam; Brandon L Bassett; Ping Wu
Journal:  Neurosci Lett       Date:  2007-01-14       Impact factor: 3.046

Review 3.  Retrograde axonal transport and motor neuron disease.

Authors:  Anna-Lena Ström; Jozsef Gal; Ping Shi; Edward J Kasarskis; Lawrence J Hayward; Haining Zhu
Journal:  J Neurochem       Date:  2008-04-01       Impact factor: 5.372

4.  A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS.

Authors:  Theo Hatzipetros; Joshua D Kidd; Andy J Moreno; Kenneth Thompson; Alan Gill; Fernando G Vieira
Journal:  J Vis Exp       Date:  2015-10-06       Impact factor: 1.355

Review 5.  The role of the leukemia inhibitory factor receptor in neuroprotective signaling.

Authors:  Stephanie M Davis; Keith R Pennypacker
Journal:  Pharmacol Ther       Date:  2017-08-19       Impact factor: 12.310

6.  Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.

Authors:  Stephanie M Davis; Lisa A Collier; Sarah Goodwin; Douglas E Lukins; David K Powell; Keith R Pennypacker
Journal:  Brain Res       Date:  2018-11-13       Impact factor: 3.252

7.  Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model.

Authors:  C R Hayworth; F Gonzalez-Lima
Journal:  Neuroscience       Date:  2009-08-20       Impact factor: 3.590

8.  Time-course and characterization of orolingual motor deficits in B6SJL-Tg(SOD1-G93A)1Gur/J mice.

Authors:  S E Smittkamp; J W Brown; J A Stanford
Journal:  Neuroscience       Date:  2007-10-30       Impact factor: 3.590

9.  An animal model of oral dysphagia in amyotrophic lateral sclerosis.

Authors:  Teresa E Lever; Ambre Gorsek; Kathleen T Cox; Kevin F O'Brien; Norman F Capra; Monica S Hough; Alexander K Murashov
Journal:  Dysphagia       Date:  2008-12-24       Impact factor: 3.438

10.  Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Authors:  Sara Oliván; Ana Cristina Calvo; Amaya Rando; María Jesús Muñoz; Pilar Zaragoza; Rosario Osta
Journal:  Exp Anim       Date:  2014-12-20
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