| Literature DB >> 28824290 |
Yunpeng Liu1,2, Liuqing Wen2, Lei Li2, Madhusudhan Reddy Gadi2, Wanyi Guan2, Kenneth Huang2, Zhongying Xiao2, Mohui Wei2, Cheng Ma2, Qing Zhang2, Hai Yu3, Xi Chen3, Peng George Wang1,2, Junqiang Fang1.
Abstract
A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl N-phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.Entities:
Keywords: N-phenyltrifluoroacetimidate; chemoenzymatic; enzymatic synthesis; glycosphingolipids; glycosylation
Year: 2016 PMID： 28824290 PMCID： PMC5560440 DOI： 10.1002/ejoc.201600950
Source DB: PubMed Journal: European J Org Chem ISSN： 1099-0690