BACKGROUND: Anemia is common in chronic kidney disease (CKD) and may be associated with mortality in CKD patients. However, few studies have examined this relationship in Asian populations. METHODS: A total of 62,931 Japanese people (age 64.0 ± 8.0 years; men 38.5%) were followed up from 2008 to 2012. Participants were divided into six groups in accordance with their estimated glomerular filtration rate (eGFR) (<45, 45-59, ≥60 mL/min/1.73 m2) and by hemoglobin levels (13.0 g/dL for men; 12.0 g/dL for women). Hazard ratio and confidence interval (CI) for mortality with a combination of eGFR and anemia were calculated. After matching using propensity score (PS) for anemia, survival analysis between anemic and non-anemic people, independent from some variables, including eGFR, was performed. RESULTS: A total of 828 (1.3%) participants died (non-anemic vs. anemic, 1.2 vs. 2.3%, p < 0.01). Multivariable Cox analysis showed that, independent of eGFR levels, anemic people had significantly higher mortality. Anemic people were found to have significantly poorer survival than non-anemic people as per a log-rank test (p < 0.01) for the PS-matching cohort. Further stratified logistic analysis using PS in the overall cohort odds ratio (95% CI) showed 2.25 (1.89-2.67) with p < 0.01. CONCLUSION: The results of the present study showed that anemia was an independent risk factor of all-cause mortality.
BACKGROUND:Anemia is common in chronic kidney disease (CKD) and may be associated with mortality in CKDpatients. However, few studies have examined this relationship in Asian populations. METHODS: A total of 62,931 Japanese people (age 64.0 ± 8.0 years; men 38.5%) were followed up from 2008 to 2012. Participants were divided into six groups in accordance with their estimated glomerular filtration rate (eGFR) (<45, 45-59, ≥60 mL/min/1.73 m2) and by hemoglobin levels (13.0 g/dL for men; 12.0 g/dL for women). Hazard ratio and confidence interval (CI) for mortality with a combination of eGFR and anemia were calculated. After matching using propensity score (PS) for anemia, survival analysis between anemic and non-anemic people, independent from some variables, including eGFR, was performed. RESULTS: A total of 828 (1.3%) participants died (non-anemic vs. anemic, 1.2 vs. 2.3%, p < 0.01). Multivariable Cox analysis showed that, independent of eGFR levels, anemic people had significantly higher mortality. Anemic people were found to have significantly poorer survival than non-anemic people as per a log-rank test (p < 0.01) for the PS-matching cohort. Further stratified logistic analysis using PS in the overall cohort odds ratio (95% CI) showed 2.25 (1.89-2.67) with p < 0.01. CONCLUSION: The results of the present study showed that anemia was an independent risk factor of all-cause mortality.
Authors: B Daan Westenbrink; Erik Lipsic; Peter van der Meer; Pim van der Harst; Hisko Oeseburg; Gideon J Du Marchie Sarvaas; Johan Koster; Adriaan A Voors; Dirk J van Veldhuisen; Wiek H van Gilst; Regien G Schoemaker Journal: Eur Heart J Date: 2007-06-17 Impact factor: 29.983
Authors: Jerome L Abramson; Claudine T Jurkovitz; Viola Vaccarino; William S Weintraub; William McClellan Journal: Kidney Int Date: 2003-08 Impact factor: 10.612
Authors: Claudine T Jurkovitz; Jerome L Abramson; L Viola Vaccarino; William S Weintraub; William M McClellan Journal: J Am Soc Nephrol Date: 2003-11 Impact factor: 10.121
Authors: Yongmei Liu; Josef Coresh; Joseph A Eustace; J Craig Longenecker; Bernard Jaar; Nancy E Fink; Russell P Tracy; Neil R Powe; Michael J Klag Journal: JAMA Date: 2004-01-28 Impact factor: 56.272
Authors: Adam J Rudinsky; Laura M Harjes; Julie Byron; Dennis J Chew; Ramiro E Toribio; Catherine Langston; Valerie J Parker Journal: J Vet Intern Med Date: 2018-10-16 Impact factor: 3.333