| Literature DB >> 2881522 |
M Sansone, C Castellano, F R D'Amato.
Abstract
Three histamine H1-receptor antagonists, chlorpheniramine, diphenhydramine and tripelennamine, were tested alone or in combination with morphine on locomotor activity in C57BL/6 mice. All three antihistaminics, at some dosage levels, slightly increased activity when given alone, but strongly enhanced morphine-induced hyperactivity. The results demonstrate that locomotor activity represents a useful test to evidence stimulatory effects of antihistaminic-opiate combinations.Entities:
Mesh：
Substances：
Year: 1986 PMID： 2881522
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780